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Items: 1 to 20 of 471

1.

Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain.

Pechous R, Celli J, Penoske R, Hayes SF, Frank DW, Zahrt TC.

Infect Immun. 2006 Aug;74(8):4452-61.

2.

A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.

Pechous RD, McCarthy TR, Mohapatra NP, Soni S, Penoske RM, Salzman NH, Frank DW, Gunn JS, Zahrt TC.

PLoS One. 2008 Jun 25;3(6):e2487. doi: 10.1371/journal.pone.0002487.

4.

A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.

Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL.

Infect Immun. 2007 May;75(5):2591-602. Epub 2007 Feb 12.

5.

Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS.

Li J, Ryder C, Mandal M, Ahmed F, Azadi P, Snyder DS, Pechous RD, Zahrt T, Inzana TJ.

Microbiology. 2007 Sep;153(Pt 9):3141-53.

PMID:
17768257
6.

Identification of a live attenuated vaccine candidate for tularemia prophylaxis.

Mahawar M, Rabadi SM, Banik S, Catlett SV, Metzger DW, Malik M, Bakshi CS.

PLoS One. 2013 Apr 17;8(4):e61539. doi: 10.1371/journal.pone.0061539. Print 2013.

7.

Deletion of IglH in virulent Francisella tularensis subsp. holarctica FSC200 strain results in attenuation and provides protection against the challenge with the parental strain.

Straskova A, Cerveny L, Spidlova P, Dankova V, Belcic D, Santic M, Stulik J.

Microbes Infect. 2012 Feb;14(2):177-87. doi: 10.1016/j.micinf.2011.08.017. Epub 2011 Sep 8.

PMID:
21930232
9.

A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.

Twine S, Byström M, Chen W, Forsman M, Golovliov I, Johansson A, Kelly J, Lindgren H, Svensson K, Zingmark C, Conlan W, Sjöstedt A.

Infect Immun. 2005 Dec;73(12):8345-52.

10.

Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.

Cong Y, Yu JJ, Guentzel MN, Berton MT, Seshu J, Klose KE, Arulanandam BP.

Vaccine. 2009 Sep 18;27(41):5554-61. doi: 10.1016/j.vaccine.2009.07.034. Epub 2009 Aug 3.

11.

Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria: effects of host background and route of immunization.

Conlan JW, Shen H, Golovliov I, Zingmark C, Oyston PC, Chen W, House RV, Sjöstedt A.

Vaccine. 2010 Feb 17;28(7):1824-31. doi: 10.1016/j.vaccine.2009.12.001. Epub 2009 Dec 16.

12.

A ΔclpB mutant of Francisella tularensis subspecies holarctica strain, FSC200, is a more effective live vaccine than F. tularensis LVS in a mouse respiratory challenge model of tularemia.

Golovliov I, Twine SM, Shen H, Sjostedt A, Conlan W.

PLoS One. 2013 Nov 13;8(11):e78671. doi: 10.1371/journal.pone.0078671. eCollection 2013.

13.

Interleukin-17 protects against the Francisella tularensis live vaccine strain but not against a virulent F. tularensis type A strain.

Skyberg JA, Rollins MF, Samuel JW, Sutherland MD, Belisle JT, Pascual DW.

Infect Immun. 2013 Sep;81(9):3099-105. doi: 10.1128/IAI.00203-13. Epub 2013 Jun 17.

14.

Models derived from in vitro analyses of spleen, liver, and lung leukocyte functions predict vaccine efficacy against the Francisella tularensis Live Vaccine Strain (LVS).

De Pascalis R, Chou AY, Ryden P, Kennett NJ, Sjöstedt A, Elkins KL.

MBio. 2014 Apr 8;5(2):e00936. doi: 10.1128/mBio.00936-13.

15.

A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice.

Quarry JE, Isherwood KE, Michell SL, Diaper H, Titball RW, Oyston PC.

Vaccine. 2007 Mar 1;25(11):2011-8. Epub 2006 Dec 8.

PMID:
17241711
17.

Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain.

Sanapala S, Yu JJ, Murthy AK, Li W, Guentzel MN, Chambers JP, Klose KE, Arulanandam BP.

Infect Immun. 2012 Jun;80(6):2177-85. doi: 10.1128/IAI.00036-12. Epub 2012 Apr 9.

18.

Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates.

Santiago AE, Mann BJ, Qin A, Cunningham AL, Cole LE, Grassel C, Vogel SN, Levine MM, Barry EM.

Pathog Dis. 2015 Aug;73(6):ftv036. doi: 10.1093/femspd/ftv036. Epub 2015 May 17.

19.

An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain.

Bakshi CS, Malik M, Mahawar M, Kirimanjeswara GS, Hazlett KR, Palmer LE, Furie MB, Singh R, Melendez JA, Sellati TJ, Metzger DW.

Vaccine. 2008 Sep 26;26(41):5276-88. doi: 10.1016/j.vaccine.2008.07.051. Epub 2008 Aug 8.

20.

Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation.

Ulland TK, Janowski AM, Buchan BW, Faron M, Cassel SL, Jones BD, Sutterwala FS.

Infect Immun. 2013 Jan;81(1):201-8. doi: 10.1128/IAI.00991-12. Epub 2012 Oct 31.

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