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A tyrosine-sulfated peptide derived from the heavy-chain CDR3 region of an HIV-1-neutralizing antibody binds gp120 and inhibits HIV-1 infection.

Dorfman T, Moore MJ, Guth AC, Choe H, Farzan M.

J Biol Chem. 2006 Sep 29;281(39):28529-35. Epub 2006 Jul 18.


Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.

Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M.

Cell. 2003 Jul 25;114(2):161-70.


A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry.

Farzan M, Vasilieva N, Schnitzler CE, Chung S, Robinson J, Gerard NP, Gerard C, Choe H, Sodroski J.

J Biol Chem. 2000 Oct 27;275(43):33516-21.


Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.

Huang CC, Lam SN, Acharya P, Tang M, Xiang SH, Hussan SS, Stanfield RL, Robinson J, Sodroski J, Wilson IA, Wyatt R, Bewley CA, Kwong PD.

Science. 2007 Sep 28;317(5846):1930-4.


Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.

Brower ET, Schön A, Klein JC, Freire E.

Biochemistry. 2009 Feb 3;48(4):779-85. doi: 10.1021/bi8021476.


Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry.

Lam SN, Acharya P, Wyatt R, Kwong PD, Bewley CA.

Bioorg Med Chem. 2008 Dec 1;16(23):10113-20. doi: 10.1016/j.bmc.2008.10.005. Epub 2008 Oct 5.


Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120.

Cormier EG, Persuh M, Thompson DA, Lin SW, Sakmar TP, Olson WC, Dragic T.

Proc Natl Acad Sci U S A. 2000 May 23;97(11):5762-7.


Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry.

Cimbro R, Peterson FC, Liu Q, Guzzo C, Zhang P, Miao H, Van Ryk D, Ambroggio X, Hurt DE, De Gioia L, Volkman BF, Dolan MA, Lusso P.

EBioMedicine. 2016 Aug;10:45-54. doi: 10.1016/j.ebiom.2016.06.037. Epub 2016 Jun 26.


A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120.

Quinlan BD, Joshi VR, Gardner MR, Ebrahimi KH, Farzan M.

J Virol. 2014 Mar;88(6):3353-8. doi: 10.1128/JVI.03800-13. Epub 2014 Jan 3.


Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region.

Farzan M, Chung S, Li W, Vasilieva N, Wright PL, Schnitzler CE, Marchione RJ, Gerard C, Gerard NP, Sodroski J, Choe H.

J Biol Chem. 2002 Oct 25;277(43):40397-402. Epub 2002 Aug 14.


Reversible and efficient activation of HIV-1 cell entry by a tyrosine-sulfated peptide dissects endocytic entry and inhibitor mechanisms.

Platt EJ, Gomes MM, Kabat D.

J Virol. 2014 Apr;88(8):4304-18. doi: 10.1128/JVI.03447-13. Epub 2014 Jan 29.


Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody.

Xiang SH, Farzan M, Si Z, Madani N, Wang L, Rosenberg E, Robinson J, Sodroski J.

J Virol. 2005 May;79(10):6068-77.


CCR5 N-terminus peptides enhance X4 HIV-1 infection by CXCR4 up-regulation.

Dettin M, Zanchetta M, Pasquato A, Borrello M, Piatier-Tonneau D, Di Bello C, De Rossi A.

Biochem Biophys Res Commun. 2003 Aug 1;307(3):640-6.


Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.

Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-ul-Hussan S, Clore GM, Kwong PD, Bewley CA.

J Biol Chem. 2012 Apr 27;287(18):15076-86. doi: 10.1074/jbc.M111.332361. Epub 2012 Mar 8.


A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs.

de Parseval A, Bobardt MD, Chatterji A, Chatterji U, Elder JH, David G, Zolla-Pazner S, Farzan M, Lee TH, Gallay PA.

J Biol Chem. 2005 Nov 25;280(47):39493-504. Epub 2005 Sep 12.


CCR5 mimicry by sulfated human anti-HIV-1 antibodies.

Lin G, Hoxie JA.

Cell. 2003 Jul 25;114(2):147-8.


A tyrosine-sulfated CCR5-mimetic peptide promotes conformational transitions in the HIV-1 envelope glycoprotein.

Kwong JA, Dorfman T, Quinlan BD, Chiang JJ, Ahmed AA, Choe H, Farzan M.

J Virol. 2011 Aug;85(15):7563-71. doi: 10.1128/JVI.00630-11. Epub 2011 May 25.


The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide.

Schnur E, Noah E, Ayzenshtat I, Sargsyan H, Inui T, Ding FX, Arshava B, Sagi Y, Kessler N, Levy R, Scherf T, Naider F, Anglister J.

J Mol Biol. 2011 Jul 29;410(5):778-97. doi: 10.1016/j.jmb.2011.04.023. Erratum in: J Mol Biol. 2012 Apr 20;418(1-2):127.

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