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Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.

Celli GB, Denchi EL, de Lange T.

Nat Cell Biol. 2006 Aug;8(8):885-90. Epub 2006 Jul 16.


No overt nucleosome eviction at deprotected telomeres.

Wu P, de Lange T.

Mol Cell Biol. 2008 Sep;28(18):5724-35. doi: 10.1128/MCB.01764-07. Epub 2008 Jul 14.


Removal of shelterin reveals the telomere end-protection problem.

Sfeir A, de Lange T.

Science. 2012 May 4;336(6081):593-7. doi: 10.1126/science.1218498.


DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion.

Celli GB, de Lange T.

Nat Cell Biol. 2005 Jul;7(7):712-8. Epub 2005 Jun 19.


BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.

Badie S, Carlos AR, Folio C, Okamoto K, Bouwman P, Jonkers J, Tarsounas M.

EMBO J. 2015 Feb 3;34(3):410-24. doi: 10.15252/embj.201488947. Epub 2015 Jan 12. Erratum in: EMBO J. 2015 Mar 12;34(6):828.


TRF2 interaction with Ku heterotetramerization interface gives insight into c-NHEJ prevention at human telomeres.

Ribes-Zamora A, Indiviglio SM, Mihalek I, Williams CL, Bertuch AA.

Cell Rep. 2013 Oct 17;5(1):194-206. doi: 10.1016/j.celrep.2013.08.040. Epub 2013 Oct 3.


Multiple roles for MRE11 at uncapped telomeres.

Deng Y, Guo X, Ferguson DO, Chang S.

Nature. 2009 Aug 13;460(7257):914-8. doi: 10.1038/nature08196. Epub 2009 Jul 26.


DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.

Smogorzewska A, Karlseder J, Holtgreve-Grez H, Jauch A, de Lange T.

Curr Biol. 2002 Oct 1;12(19):1635-44.


Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.

Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T.

Science. 2010 Mar 26;327(5973):1657-61. doi: 10.1126/science.1185100.


Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

Denchi EL, de Lange T.

Nature. 2007 Aug 30;448(7157):1068-71. Epub 2007 Aug 8.


Ku70 and non-homologous end joining protect testicular cells from DNA damage.

Ahmed EA, Sfeir A, Takai H, Scherthan H.

J Cell Sci. 2013 Jul 15;126(Pt 14):3095-104. doi: 10.1242/jcs.122788.


Human LIGIV is synthetically lethal with the loss of Rad54B-dependent recombination and is required for certain chromosome fusion events induced by telomere dysfunction.

Oh S, Wang Y, Zimbric J, Hendrickson EA.

Nucleic Acids Res. 2013 Feb 1;41(3):1734-49. doi: 10.1093/nar/gks1326. Epub 2012 Dec 28.


Protection of mammalian telomeres.

de Lange T.

Oncogene. 2002 Jan 21;21(4):532-40. Review.


The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.

Rai R, Zheng H, He H, Luo Y, Multani A, Carpenter PB, Chang S.

EMBO J. 2010 Aug 4;29(15):2598-610. doi: 10.1038/emboj.2010.142. Epub 2010 Jun 29.


Ku80 facilitates chromatin binding of the telomere binding protein, TRF2.

Fink LS, Lerner CA, Torres PF, Sell C.

Cell Cycle. 2010 Sep 15;9(18):3798-806. Epub 2010 Sep 25.


53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility.

Dimitrova N, Chen YC, Spector DL, de Lange T.

Nature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008 Oct 19.


DNA repair factors and telomere-chromosome integrity in mammalian cells.

Hande MP.

Cytogenet Genome Res. 2004;104(1-4):116-22. Review.


A two-step mechanism for TRF2-mediated chromosome-end protection.

Okamoto K, Bartocci C, Ouzounov I, Diedrich JK, Yates JR 3rd, Denchi EL.

Nature. 2013 Feb 28;494(7438):502-5. doi: 10.1038/nature11873. Epub 2013 Feb 6.


TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends.

Bombarde O, Boby C, Gomez D, Frit P, Giraud-Panis MJ, Gilson E, Salles B, Calsou P.

EMBO J. 2010 May 5;29(9):1573-84. doi: 10.1038/emboj.2010.49. Epub 2010 Apr 20.

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