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Items: 1 to 20 of 99

1.

Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.

Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J.

J Proteome Res. 2006 Jul;5(7):1586-601.

PMID:
16823966
2.
3.

Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue.

Auman JT, Chou J, Gerrish K, Huang Q, Jayadev S, Blanchard K, Paules RS.

Environ Health Perspect. 2007 Apr;115(4):572-8. Epub 2007 Jan 17.

4.

Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.

Ratra GS, Cottrell S, Powell CJ.

Toxicol Sci. 1998 Nov;46(1):185-96.

PMID:
9928682
5.

Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats.

Slopianka M, Herrmann A, Pavkovic M, Ellinger-Ziegelbauer H, Ernst R, Mally A, Keck M, Riefke B.

Toxicology. 2017 Jul 1;386:1-10. doi: 10.1016/j.tox.2017.05.009. Epub 2017 May 19.

PMID:
28529062
6.

Methapyrilene toxicity: anchorage of pathologic observations to gene expression alterations.

Hamadeh HK, Knight BL, Haugen AC, Sieber S, Amin RP, Bushel PR, Stoll R, Blanchard K, Jayadev S, Tennant RW, Cunningham ML, Afshari CA, Paules RS.

Toxicol Pathol. 2002 Jul-Aug;30(4):470-82.

PMID:
12187938
7.

Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.

Ratra GS, Powell CJ, Park BK, Maggs JL, Cottrell S.

Chem Biol Interact. 2000 Dec 15;129(3):279-95.

PMID:
11137066
8.
9.

Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.

Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T.

J Toxicol Sci. 2008 Feb;33(1):37-50.

10.

Dose-dependent induction of GST-P+ staining foci by the rat hepatocarcinogen methapyrilene in the medium-term bioassay.

Horn DM, Jordan WH, Holloway DC, Smith WC, Richardson FC.

Fundam Appl Toxicol. 1996 Feb;29(2):194-7.

PMID:
8742315
11.

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK.

J Pharmacol Exp Ther. 2008 Aug;326(2):657-71. doi: 10.1124/jpet.107.135483. Epub 2008 May 1.

12.

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo.

Priestley CC, Regan S, Kevin Park B, Williams DP.

Toxicology. 2011 Dec 18;290(2-3):249-57. doi: 10.1016/j.tox.2011.10.002. Epub 2011 Oct 12.

PMID:
22015589
13.
14.

Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro.

Kindrat I, Dreval K, Shpyleva S, Tryndyak V, de Conti A, Mudalige TK, Chen T, Erstenyuk AM, Beland FA, Pogribny IP.

Toxicol Lett. 2017 Nov 5;281:65-73. doi: 10.1016/j.toxlet.2017.09.011. Epub 2017 Sep 19.

PMID:
28935588
16.

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK.

Toxicol Appl Pharmacol. 2009 Sep 15;239(3):297-305. doi: 10.1016/j.taap.2009.05.027. Epub 2009 Jun 10.

PMID:
19523481
17.

Systems toxicology used in nanotoxicology: mechanistic insights into the hepatotoxicity of nano-copper particles from toxicogenomics.

Yang B, Wang Q, Lei R, Wu C, Shi C, Wang Q, Yuan Y, Wang Y, Luo Y, Hu Z, Ma H, Liao M.

J Nanosci Nanotechnol. 2010 Dec;10(12):8527-37.

PMID:
21121362
18.

Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology.

Graichen ME, Neptun DA, Dent JG, Popp JA, Leonard TB.

Fundam Appl Toxicol. 1985 Feb;5(1):165-74.

PMID:
2859228
19.

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.

Leitch AC, Probert PME, Shayman JA, Meyer SK, Kass GEN, Wright MC.

Toxicology. 2017 Jul 1;386:120-132. doi: 10.1016/j.tox.2017.05.014. Epub 2017 May 26.

20.

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