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Items: 1 to 20 of 116

1.

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.

Chowdhury D, Beresford PJ, Zhu P, Zhang D, Sung JS, Demple B, Perrino FW, Lieberman J.

Mol Cell. 2006 Jul 7;23(1):133-42.

2.

Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.

Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J.

Cell. 2003 Mar 7;112(5):659-72. Erratum in: Cell. 2003 Oct 17;115(2):241.

3.

Nuclear war: the granzyme A-bomb.

Lieberman J, Fan Z.

Curr Opin Immunol. 2003 Oct;15(5):553-9. Review.

PMID:
14499264
4.

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks.

Beresford PJ, Zhang D, Oh DY, Fan Z, Greer EL, Russo ML, Jaju M, Lieberman J.

J Biol Chem. 2001 Nov 16;276(46):43285-93. Epub 2001 Sep 12.

5.

Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.

Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J.

Nat Immunol. 2003 Feb;4(2):145-53. Epub 2003 Jan 13.

PMID:
12524539
6.
7.

Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells.

Zhao T, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z.

Cell Death Differ. 2007 Mar;14(3):489-99. Epub 2006 Sep 29.

8.

Crystal structure of the apoptosis-inducing human granzyme A dimer.

Hink-Schauer C, Estébanez-Perpiñá E, Kurschus FC, Bode W, Jenne DE.

Nat Struct Biol. 2003 Jul;10(7):535-40.

PMID:
12819770
9.

Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.

Niitsu N, Nakamine H, Okamoto M, Akamatsu H, Honma Y, Higashihara M, Okabe-Kado J, Hirano M; Adult Lymphoma Treatment Study Group, ALTSG.

Br J Haematol. 2003 Nov;123(4):621-30.

PMID:
14616965
10.

Granzyme M mediates a novel form of perforin-dependent cell death.

Kelly JM, Waterhouse NJ, Cretney E, Browne KA, Ellis S, Trapani JA, Smyth MJ.

J Biol Chem. 2004 May 21;279(21):22236-42. Epub 2004 Mar 17.

12.

Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression.

Kaetzel DM, Zhang Q, Yang M, McCorkle JR, Ma D, Craven RJ.

J Bioenerg Biomembr. 2006 Aug;38(3-4):163-7. Review.

PMID:
17039395
13.

SET-ting the stage for life and death.

Chakravarti D, Hong R.

Cell. 2003 Mar 7;112(5):589-91. Review.

14.

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus.

Lee-Kirsch MA, Chowdhury D, Harvey S, Gong M, Senenko L, Engel K, Pfeiffer C, Hollis T, Gahr M, Perrino FW, Lieberman J, Hubner N.

J Mol Med (Berl). 2007 May;85(5):531-7. Epub 2007 Apr 18.

PMID:
17440703
15.

Induction of rapid histone degradation by the cytotoxic T lymphocyte protease Granzyme A.

Zhang D, Pasternack MS, Beresford PJ, Wagner L, Greenberg AH, Lieberman J.

J Biol Chem. 2001 Feb 2;276(5):3683-90. Epub 2000 Nov 1.

16.

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity.

Guo Y, Chen J, Zhao T, Fan Z.

Mol Immunol. 2008 Apr;45(8):2225-35. doi: 10.1016/j.molimm.2007.11.020. Epub 2008 Jan 7.

PMID:
18179823
17.

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

Lee-Kirsch MA, Gong M, Chowdhury D, Senenko L, Engel K, Lee YA, de Silva U, Bailey SL, Witte T, Vyse TJ, Kere J, Pfeiffer C, Harvey S, Wong A, Koskenmies S, Hummel O, Rohde K, Schmidt RE, Dominiczak AF, Gahr M, Hollis T, Perrino FW, Lieberman J, Hübner N.

Nat Genet. 2007 Sep;39(9):1065-7. Epub 2007 Jul 29.

PMID:
17660818
19.

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

Estella E, McKenzie MD, Catterall T, Sutton VR, Bird PI, Trapani JA, Kay TW, Thomas HE.

Diabetes. 2006 Aug;55(8):2212-9.

20.

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