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Items: 1 to 20 of 187

1.

The discovery and role of CD147 as a subunit of gamma-secretase complex.

Zhou S, Zhou H, Walian PJ, Jap BK.

Drug News Perspect. 2006 Apr;19(3):133-8. Review.

PMID:
16804564
2.

CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.

Zhou S, Zhou H, Walian PJ, Jap BK.

Proc Natl Acad Sci U S A. 2005 May 24;102(21):7499-504. Epub 2005 May 12.

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Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
6.

Partial purification and characterization of gamma-secretase from post-mortem human brain.

Farmery MR, Tjernberg LO, Pursglove SE, Bergman A, Winblad B, Näslund J.

J Biol Chem. 2003 Jul 4;278(27):24277-84. Epub 2003 Apr 15.

7.

Gamma-secretase--intramembrane protease with a complex.

Wolfe MS.

Sci Aging Knowledge Environ. 2003 Mar 19;2003(11):PE7.

PMID:
12844518
8.

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.

Biochemistry. 2009 Feb 17;48(6):1183-97. doi: 10.1021/bi801204g.

PMID:
19159235
9.

Presenilin function and gamma-secretase activity.

Brunkan AL, Goate AM.

J Neurochem. 2005 May;93(4):769-92. Review.

10.

[Pathogenesis of Alzheimer's disease: implications from amyloid research front].

Iwatsubo T.

Rinsho Shinkeigaku. 2004 Nov;44(11):768-70. Review. Japanese.

PMID:
15651286
11.

Secretase as a target for Alzheimer's disease.

Wolfe MS.

Curr Top Med Chem. 2002 Apr;2(4):371-83. Review.

PMID:
11966461
12.

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.

Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Jan 20;43(2):323-33.

PMID:
14717586
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Relationship between presenilinase and gamma-secretase.

Xia W.

Drug News Perspect. 2003 Mar;16(2):69-74. Review.

PMID:
12792666
16.

Uncovering gamma-secretase.

Steiner H.

Curr Alzheimer Res. 2004 Aug;1(3):175-81. Review.

PMID:
15975065
17.

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. Epub 2003 May 9.

18.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.

Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.

FEBS J. 2005 Nov;272(21):5544-57.

19.

A reporter for amyloid precursor protein gamma-secretase activity in Drosophila.

Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA.

Hum Mol Genet. 2003 Oct 15;12(20):2669-78. Epub 2003 Aug 27.

PMID:
12944419
20.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.

Nature. 2006 Apr 27;440(7088):1208-12.

PMID:
16641999

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