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Items: 1 to 20 of 141

1.

Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice.

Li X, Need AB, Baez M, Witkin JM.

J Pharmacol Exp Ther. 2006 Oct;319(1):254-9. Epub 2006 Jun 27.

2.

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests.

Belozertseva IV, Kos T, Popik P, Danysz W, Bespalov AY.

Eur Neuropsychopharmacol. 2007 Feb;17(3):172-9. Epub 2006 Apr 21.

PMID:
16630709
3.

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist.

Tatarczyńska E, Klodzińska A, Chojnacka-Wójcik E, Palucha A, Gasparini F, Kuhn R, Pilc A.

Br J Pharmacol. 2001 Apr;132(7):1423-30.

4.

[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.

Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA.

J Pharmacol Exp Ther. 2002 Dec;303(3):1044-51.

5.

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist.

Pałucha A, Brański P, Szewczyk B, Wierońska JM, Kłak K, Pilc A.

Pharmacol Biochem Behav. 2005 Aug;81(4):901-6.

PMID:
16040106
6.
7.

Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats.

Pałucha-Poniewiera A, Szewczyk B, Pilc A.

Neuropharmacology. 2014 Jul;82:59-68. doi: 10.1016/j.neuropharm.2014.03.001. Epub 2014 Mar 12.

PMID:
24631968
8.

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.

Busse CS, Brodkin J, Tattersall D, Anderson JJ, Warren N, Tehrani L, Bristow LJ, Varney MA, Cosford ND.

Neuropsychopharmacology. 2004 Nov;29(11):1971-9.

9.

Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors.

Nowak G, Pomierny-Chamioło L, Siwek A, Niedzielska E, Pomierny B, Pałucha-Poniewiera A, Pilc A.

Neuropharmacology. 2014 Sep;84:46-51. doi: 10.1016/j.neuropharm.2014.04.016. Epub 2014 May 4.

PMID:
24796254
10.

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.

Zhu CZ, Wilson SG, Mikusa JP, Wismer CT, Gauvin DM, Lynch JJ 3rd, Wade CL, Decker MW, Honore P.

Eur J Pharmacol. 2004 Dec 15;506(2):107-18.

PMID:
15588730
11.

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine).

Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C, Cosford ND, Varney MA.

Eur J Pharmacol. 2003 Jul 18;473(1):35-40.

PMID:
12877935
12.

The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles.

Varty GB, Grilli M, Forlani A, Fredduzzi S, Grzelak ME, Guthrie DH, Hodgson RA, Lu SX, Nicolussi E, Pond AJ, Parker EM, Hunter JC, Higgins GA, Reggiani A, Bertorelli R.

Psychopharmacology (Berl). 2005 Apr;179(1):207-17. Epub 2005 Jan 29.

PMID:
15682298
14.
15.

Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5.

Fuxe K, Borroto-Escuela DO.

Expert Opin Investig Drugs. 2015;24(9):1247-60. doi: 10.1517/13543784.2015.1074175. Epub 2015 Jul 29.

PMID:
26219727
16.

DSR-98776, a novel selective mGlu5 receptor negative allosteric modulator with potent antidepressant and antimanic activity.

Kato T, Takata M, Kitaichi M, Kassai M, Inoue M, Ishikawa C, Hirose W, Yoshida K, Shimizu I.

Eur J Pharmacol. 2015 Jun 15;757:11-20. doi: 10.1016/j.ejphar.2015.03.024. Epub 2015 Mar 28.

PMID:
25823809
17.

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents.

Page ME, Szeliga P, Gasparini F, Cryan JF.

Psychopharmacology (Berl). 2005 Apr;179(1):240-6. Epub 2005 Feb 17.

PMID:
15717212
19.

Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP.

Gass JT, Olive MF.

Eur J Pharmacol. 2008 Apr 28;584(2-3):253-62. doi: 10.1016/j.ejphar.2008.02.032. Epub 2008 Feb 20.

20.

Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking.

Tessari M, Pilla M, Andreoli M, Hutcheson DM, Heidbreder CA.

Eur J Pharmacol. 2004 Sep 19;499(1-2):121-33.

PMID:
15363959

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