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Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.

Lane HC, Anand AR, Ganju RK.

Int Immunol. 2006 Aug;18(8):1315-25. Epub 2006 Jun 23.


The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.

Raghuwanshi SK, Su Y, Singh V, Haynes K, Richmond A, Richardson RM.

J Immunol. 2012 Sep 15;189(6):2824-32. doi: 10.4049/jimmunol.1201114. Epub 2012 Aug 6.


Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2.

Lin BR, Chang CC, Chen LR, Wu MH, Wang MY, Kuo IH, Chu CY, Chang KJ, Lee PH, Chen WJ, Kuo ML, Lin MT.

Mol Cancer Res. 2007 Nov;5(11):1111-23.


Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis.

Di Cioccio V, Strippoli R, Bizzarri C, Troiani G, Cervellera MN, Gloaguen I, Colagrande A, Cattozzo EM, Pagliei S, Santoni A, Colotta F, Mainiero F, Bertini R.

Immunology. 2004 Apr;111(4):407-15.


G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions.

Singh V, Raghuwanshi SK, Smith N, Rivers EJ, Richardson RM.

J Immunol. 2014 Mar 1;192(5):2186-94. doi: 10.4049/jimmunol.1301875. Epub 2014 Feb 7.


Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation.

Richardson RM, Marjoram RJ, Barak LS, Snyderman R.

J Immunol. 2003 Mar 15;170(6):2904-11.


Regulation of CXCR4-mediated chemotaxis and chemoinvasion of breast cancer cells.

Fernandis AZ, Prasad A, Band H, Klösel R, Ganju RK.

Oncogene. 2004 Jan 8;23(1):157-67.


CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2: cytoskeleton- and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner.

Cohen-Hillel E, Yron I, Meshel T, Soria G, Attal H, Ben-Baruch A.

Cytokine. 2006 Jan 7;33(1):1-16. Epub 2006 Jan 9.


Intracellular trafficking of human CXCR1 and CXCR2: regulation by receptor domains and actin-related kinases.

Matityahu E, Feniger-Barish R, Meshel T, Zaslaver A, Ben-Baruch A.

Eur J Immunol. 2002 Dec;32(12):3525-35.


Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII.

Campbell M, Trimble ER.

Circ Res. 2005 Feb 4;96(2):197-206. Epub 2004 Dec 9.


Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer.

Nasser MW, Raghuwanshi SK, Grant DJ, Jala VR, Rajarathnam K, Richardson RM.

J Immunol. 2009 Sep 1;183(5):3425-32. doi: 10.4049/jimmunol.0900305. Epub 2009 Aug 10.


CXCR1 and CXCR2 activation and regulation. Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization.

Nasser MW, Raghuwanshi SK, Malloy KM, Gangavarapu P, Shim JY, Rajarathnam K, Richardson RM.

J Biol Chem. 2007 Mar 2;282(9):6906-15. Epub 2007 Jan 4.


The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.

Rorsman C, Tsioumpekou M, Heldin CH, Lennartsson J.

J Biol Chem. 2016 May 27;291(22):11608-18. doi: 10.1074/jbc.M115.705814. Epub 2016 Apr 5.


Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.

Sai J, Raman D, Liu Y, Wikswo J, Richmond A.

J Biol Chem. 2008 Sep 26;283(39):26538-47. doi: 10.1074/jbc.M805611200. Epub 2008 Jul 28.


Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2.

Kaur M, Singh D.

J Pharmacol Exp Ther. 2013 Oct;347(1):173-80. doi: 10.1124/jpet.112.201855. Epub 2013 Aug 2.


The C-terminal domain LLKIL motif of CXCR2 is required for ligand-mediated polarization of early signals during chemotaxis.

Sai J, Fan GH, Wang D, Richmond A.

J Cell Sci. 2004 Nov 1;117(Pt 23):5489-96. Epub 2004 Oct 12.


Enhancement of fcgamma receptor-mediated phagocytosis by transforming mutants of Cbl.

Sato N, Kim MK, Schreiber AD.

J Immunol. 1999 Dec 1;163(11):6123-31.


Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.

Kassenbrock CK, Hunter S, Garl P, Johnson GL, Anderson SM.

J Biol Chem. 2002 Jul 12;277(28):24967-75. Epub 2002 May 6.


Combined anti CXC receptors 1 and 2 therapy is a promising anti-inflammatory treatment for respiratory diseases by reducing neutrophil migration and activation.

Planagumà A, Domènech T, Pont M, Calama E, García-González V, López R, Aulí M, López M, Fonquerna S, Ramos I, de Alba J, Nueda A, Prats N, Segarra V, Miralpeix M, Lehner MD.

Pulm Pharmacol Ther. 2015 Oct;34:37-45. doi: 10.1016/j.pupt.2015.08.002. Epub 2015 Aug 10. Review.


Functional activity of CXCL8 receptors, CXCR1 and CXCR2, on human malignant melanoma progression.

Gabellini C, Trisciuoglio D, Desideri M, Candiloro A, Ragazzoni Y, Orlandi A, Zupi G, Del Bufalo D.

Eur J Cancer. 2009 Sep;45(14):2618-27. doi: 10.1016/j.ejca.2009.07.007. Epub 2009 Aug 13.


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