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Items: 1 to 20 of 305

1.

Protein phosphorylation and signal transduction modulation: chemistry perspectives for small-molecule drug discovery.

Sawyer TK, Shakespeare WC, Wang Y, Sundaramoorthi R, Huang WS, Metcalf CA 3rd, Thomas M, Lawrence BM, Rozamus L, Noehre J, Zhu X, Narula S, Bohacek RS, Weigele M, Dalgarno DC.

Med Chem. 2005 May;1(3):293-319. Review.

PMID:
16787325
2.

Signal transduction drug discovery: targets, mechanisms and structure-based design.

Dalgarno DC, Metcalf CA Jr, Shakespeare WC, Sawyer TK.

Curr Opin Drug Discov Devel. 2000 Sep;3(5):549-64.

PMID:
19649883
3.

Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.

Sawyer TK.

Expert Opin Investig Drugs. 2004 Jan;13(1):1-19. Review. Erratum in: Expert Opin Investig Drugs. 2004 Feb;13(2):173.

PMID:
14680449
4.

SRC homology-2 inhibitors: peptidomimetic and nonpeptide.

Sawyer TK, Bohacek RS, Dalgarno DC, Eyermann CJ, Kawahata N, Metcalf CA 3rd, Shakespeare WC, Sundaramoorthi R, Wang Y, Yang MG.

Mini Rev Med Chem. 2002 Oct;2(5):475-88. Review.

PMID:
12370048
5.
6.

Studies of small molecule interactions with protein phosphatases using biosensor technology.

Stenlund P, Frostell-Karlsson A, Karlsson OP.

Anal Biochem. 2006 Jun 15;353(2):217-25. Epub 2006 Mar 20.

PMID:
16597430
7.

Docking interactions in protein kinase and phosphatase networks.

Reményi A, Good MC, Lim WA.

Curr Opin Struct Biol. 2006 Dec;16(6):676-85. Epub 2006 Oct 31. Review.

PMID:
17079133
8.

Protein kinase inhibitors: insights into drug design from structure.

Noble ME, Endicott JA, Johnson LN.

Science. 2004 Mar 19;303(5665):1800-5. Review.

PMID:
15031492
9.

High-throughput structural biology in drug discovery: protein kinases.

Stout TJ, Foster PG, Matthews DJ.

Curr Pharm Des. 2004;10(10):1069-82. Review.

PMID:
15078142
10.

Chemical approaches to reversible protein phosphorylation.

Cole PA, Courtney AD, Shen K, Zhang Z, Qiao Y, Lu W, Williams DM.

Acc Chem Res. 2003 Jun;36(6):444-52.

PMID:
12809531
11.

Small molecule inhibitors of serine/threonine protein phosphatases.

McCluskey A, Sakoff JA.

Mini Rev Med Chem. 2001 May;1(1):43-55. Review.

PMID:
12369990
12.

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM.

Circulation. 2004 Mar 16;109(10):1196-205. Review.

14.

Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?

Honkanen RE, Golden T.

Curr Med Chem. 2002 Nov;9(22):2055-75. Review.

PMID:
12369870
15.

[Protein phosphatases: structure and function].

Bulanova EG, Budagian VM.

Mol Biol (Mosk). 1994 Sep-Oct;28(5):991-1001. Review. Russian.

PMID:
7990844
16.

Discovery of protein kinase phosphatase inhibitors.

Vogt A, Lazo JS.

Methods Mol Biol. 2007;356:389-400.

PMID:
16988418
17.
18.

Structure-based drug design of new leads for phosphatase research.

Combs AP.

IDrugs. 2007 Feb;10(2):112-5. Review.

PMID:
17285463
19.

Regulation of gene expression by serine/threonine protein phosphatases.

Schönthal AH.

Semin Cancer Biol. 1995 Aug;6(4):239-48. Review.

PMID:
8541519
20.

Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors.

Arnold DM, Foster C, Huryn DM, Lazo JS, Johnston PA, Wipf P.

Chem Biol Drug Des. 2007 Jan;69(1):23-30.

PMID:
17313454

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