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Items: 1 to 20 of 128


Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.

Benzeno S, Lu F, Guo M, Barbash O, Zhang F, Herman JG, Klein PS, Rustgi A, Diehl JA.

Oncogene. 2006 Oct 12;25(47):6291-303. Epub 2006 May 29.


An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.

Lu F, Gladden AB, Diehl JA.

Cancer Res. 2003 Nov 1;63(21):7056-61.


Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

Barbash O, Zamfirova P, Lin DI, Chen X, Yang K, Nakagawa H, Lu F, Rustgi AK, Diehl JA.

Cancer Cell. 2008 Jul 8;14(1):68-78. doi: 10.1016/j.ccr.2008.05.017.


p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export.

Alt JR, Gladden AB, Diehl JA.

J Biol Chem. 2002 Mar 8;277(10):8517-23. Epub 2001 Dec 20.


A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells.

Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS.

J Biol Chem. 2008 Sep 26;283(39):26759-70. doi: 10.1074/jbc.M802160200. Epub 2008 Jul 23.


Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels.

Yang K, Guo Y, Stacey WC, Harwalkar J, Fretthold J, Hitomi M, Stacey DW.

BMC Cell Biol. 2006 Aug 30;7:33.


Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells.

Masamha CP, Benbrook DM.

Cancer Res. 2009 Aug 15;69(16):6565-72. doi: 10.1158/0008-5472.CAN-09-0913. Epub 2009 Jul 28.


C-terminal sequences direct cyclin D1-CRM1 binding.

Benzeno S, Diehl JA.

J Biol Chem. 2004 Dec 31;279(53):56061-6. Epub 2004 Oct 28.


Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.

Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES.

J Biol Chem. 2003 Aug 8;278(32):30339-47. Epub 2003 May 12. Erratum in: J Biol Chem. 2004 Jul 16;279(29):30914.


The involvement of cyclin D1 degradation through GSK3β-mediated threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts.

Eo HJ, Park GH, Jeong JB.

Phytomedicine. 2016 Feb 15;23(2):105-13. doi: 10.1016/j.phymed.2015.12.007. Epub 2015 Dec 29.


Insulin-like growth factor I triggers nuclear accumulation of cyclin D1 in MCF-7S breast cancer cells.

Hamelers IH, van Schaik RF, Sipkema J, Sussenbach JS, Steenbergh PH.

J Biol Chem. 2002 Dec 6;277(49):47645-52. Epub 2002 Oct 2.


Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression.

Lee Y, Dominy JE, Choi YJ, Jurczak M, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P.

Nature. 2014 Jun 26;510(7506):547-51. doi: 10.1038/nature13267. Epub 2014 May 25.


CDK4 protein is degraded by anaphase-promoting complex/cyclosome in mitosis and reaccumulates in early G1 phase to initiate a new cell cycle in HeLa cells.

Chen H, Xu X, Wang G, Zhang B, Wang G, Xin G, Liu J, Jiang Q, Zhang H, Zhang C.

J Biol Chem. 2017 Jun 16;292(24):10131-10141. doi: 10.1074/jbc.M116.773226. Epub 2017 Apr 26.


Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.

Diehl JA, Cheng M, Roussel MF, Sherr CJ.

Genes Dev. 1998 Nov 15;12(22):3499-511.

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