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Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Bao S, Jacobson DA, Wohltmann M, Bohrer A, Jin W, Philipson LH, Turk J.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E217-29. Epub 2007 Sep 25.


Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Bao S, Li Y, Lei X, Wohltmann M, Jin W, Bohrer A, Semenkovich CF, Ramanadham S, Tabas I, Turk J.

J Biol Chem. 2007 Sep 14;282(37):27100-14. Epub 2007 Jul 12.


Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

Bao S, Miller DJ, Ma Z, Wohltmann M, Eng G, Ramanadham S, Moley K, Turk J.

J Biol Chem. 2004 Sep 10;279(37):38194-200. Epub 2004 Jul 12.


Group VIA phospholipase A2 forms a signaling complex with the calcium/calmodulin-dependent protein kinase IIbeta expressed in pancreatic islet beta-cells.

Wang Z, Ramanadham S, Ma ZA, Bao S, Mancuso DJ, Gross RW, Turk J.

J Biol Chem. 2005 Feb 25;280(8):6840-9. Epub 2004 Dec 2.


Protection of pancreatic beta-cells by group VIA phospholipase A(2)-mediated repair of mitochondrial membrane peroxidation.

Zhao Z, Zhang X, Zhao C, Choi J, Shi J, Song K, Turk J, Ma ZA.

Endocrinology. 2010 Jul;151(7):3038-48. doi: 10.1210/en.2010-0016. Epub 2010 May 12. Erratum in: Endocrinology. 2011 Jan;152(1):336.


Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet.

Song H, Wohltmann M, Bao S, Ladenson JH, Semenkovich CF, Turk J.

Am J Physiol Endocrinol Metab. 2010 Jun;298(6):E1097-114. doi: 10.1152/ajpendo.00780.2009. Epub 2010 Feb 23.


Group VIA PLA2 (iPLA2β) is activated upstream of p38 mitogen-activated protein kinase (MAPK) in pancreatic islet β-cell signaling.

Song H, Wohltmann M, Tan M, Bao S, Ladenson JH, Turk J.

J Biol Chem. 2012 Feb 17;287(8):5528-41. doi: 10.1074/jbc.M111.285114. Epub 2011 Dec 22.


Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.

Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH.

J Biol Chem. 2007 Mar 9;282(10):7442-9. Epub 2006 Dec 29.


Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.

Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E587-96. doi: 10.1152/ajpendo.00177.2012. Epub 2012 Jun 26.

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