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Items: 1 to 20 of 168

2.

On the structure-based design of novel inhibitors of H5N1 influenza A virus neuraminidase (NA).

Mitrasinovic PM.

Biophys Chem. 2009 Mar;140(1-3):35-8. doi: 10.1016/j.bpc.2008.11.004. Epub 2008 Nov 20.

PMID:
19117662
3.

Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor.

Lew W, Chen X, Kim CU.

Curr Med Chem. 2000 Jun;7(6):663-72. Review.

PMID:
10702632
4.

Binding interaction analysis of the active site and its inhibitors for neuraminidase (N1 subtype) of human influenza virus by the integration of molecular docking, FMO calculation and 3D-QSAR CoMFA modeling.

Zhang Q, Yang J, Liang K, Feng L, Li S, Wan J, Xu X, Yang G, Liu D, Yang S.

J Chem Inf Model. 2008 Sep;48(9):1802-12. doi: 10.1021/ci800041k. Epub 2008 Aug 16.

PMID:
18707092
5.

Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site.

Finley JB, Atigadda VR, Duarte F, Zhao JJ, Brouillette WJ, Air GM, Luo M.

J Mol Biol. 1999 Nov 12;293(5):1107-19.

PMID:
10547289
6.

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

Kim CU, Lew W, Williams MA, Liu H, Zhang L, Swaminathan S, Bischofberger N, Chen MS, Mendel DB, Tai CY, Laver WG, Stevens RC.

J Am Chem Soc. 1997 Jan 29;119(4):681-90.

PMID:
16526129
7.

Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.

Wei DQ, Du QS, Sun H, Chou KC.

Biochem Biophys Res Commun. 2006 Jun 9;344(3):1048-55. Epub 2006 Apr 19.

PMID:
16647045
8.

Insights from investigating the interaction of oseltamivir (Tamiflu) with neuraminidase of the 2009 H1N1 swine flu virus.

Wang SQ, Du QS, Huang RB, Zhang DW, Chou KC.

Biochem Biophys Res Commun. 2009 Aug 28;386(3):432-6. doi: 10.1016/j.bbrc.2009.06.016. Epub 2009 Jun 10.

PMID:
19523442
9.

Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

Kim CU, Lew W, Williams MA, Wu H, Zhang L, Chen X, Escarpe PA, Mendel DB, Laver WG, Stevens RC.

J Med Chem. 1998 Jul 2;41(14):2451-60.

PMID:
9651151
10.

Analogue inhibitors by modifying oseltamivir based on the crystal neuraminidase structure for treating drug-resistant H5N1 virus.

Du QS, Wang SQ, Chou KC.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):525-31. Epub 2007 Aug 13.

PMID:
17707775
11.

Recent progress and challenges in the discovery of new neuraminidase inhibitors.

Chamni S, De-Eknamkul W.

Expert Opin Ther Pat. 2013 Apr;23(4):409-23. doi: 10.1517/13543776.2013.765861. Epub 2013 Feb 1. Review.

PMID:
23369206
12.
13.
14.

Guanidinobenzoic acid inhibitors of influenza virus neuraminidase.

Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M.

J Mol Biol. 1997 Apr 4;267(3):584-94.

PMID:
9126840
15.

Study on molecular mechanism and 3D-QSAR of influenza neuraminidase inhibitors.

Yi X, Guo Z, Chu FM.

Bioorg Med Chem. 2003 Apr 3;11(7):1465-74.

PMID:
12628672
17.

Binding mechanism of H5N1 influenza virus neuraminidase with ligands and its implication for drug design.

Gong K, Li L, Wang JF, Cheng F, Wei DQ, Chou KC.

Med Chem. 2009 May;5(3):242-9.

PMID:
19442214
18.

Computational design of novel, high-affinity neuraminidase inhibitors for H5N1 avian influenza virus.

Park JW, Jo WH.

Eur J Med Chem. 2010 Feb;45(2):536-41. doi: 10.1016/j.ejmech.2009.10.040. Epub 2009 Oct 31.

PMID:
19914748
19.

Rational design of Tamiflu derivatives targeting at the open conformation of neuraminidase subtype 1.

Li Y, Zhou B, Wang R.

J Mol Graph Model. 2009 Oct;28(3):203-19. doi: 10.1016/j.jmgm.2009.07.001. Epub 2009 Aug 4.

PMID:
19656699
20.

Design of multi-binding-site inhibitors, ligand efficiency, and consensus screening of avian influenza H5N1 wild-type neuraminidase and of the oseltamivir-resistant H274Y variant.

GarcĂ­a-Sosa AT, Sild S, Maran U.

J Chem Inf Model. 2008 Oct;48(10):2074-80. doi: 10.1021/ci800242z. Epub 2008 Oct 11.

PMID:
18847186

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