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UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.

Malakhova OA, Kim KI, Luo JK, Zou W, Kumar KG, Fuchs SY, Shuai K, Zhang DE.

EMBO J. 2006 Jun 7;25(11):2358-67. Epub 2006 May 18.


Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling.

Kim KI, Malakhova OA, Hoebe K, Yan M, Beutler B, Zhang DE.

J Immunol. 2005 Jul 15;175(2):847-54.


Protein ISGylation modulates the JAK-STAT signaling pathway.

Malakhova OA, Yan M, Malakhov MP, Yuan Y, Ritchie KJ, Kim KI, Peterson LF, Shuai K, Zhang DE.

Genes Dev. 2003 Feb 15;17(4):455-60.


The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.

Tokarz S, Berset C, La Rue J, Friedman K, Nakayama K, Nakayama K, Zhang DE, Lanker S.

J Biol Chem. 2004 Nov 5;279(45):46424-30. Epub 2004 Sep 1.


Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling.

Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE.

Blood. 2007 Jul 1;110(1):305-12. Epub 2007 Mar 20.


Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.

Kim KI, Yan M, Malakhova O, Luo JK, Shen MF, Zou W, de la Torre JC, Zhang DE.

Mol Cell Biol. 2006 Jan;26(2):472-9.


Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3.

Malakhova O, Malakhov M, Hetherington C, Zhang DE.

J Biol Chem. 2002 Apr 26;277(17):14703-11. Epub 2002 Feb 19.


Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43.

Sarasin-Filipowicz M, Wang X, Yan M, Duong FH, Poli V, Hilton DJ, Zhang DE, Heim MH.

Mol Cell Biol. 2009 Sep;29(17):4841-51. doi: 10.1128/MCB.00224-09. Epub 2009 Jun 29.


Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice.

Knobeloch KP, Utermöhlen O, Kisser A, Prinz M, Horak I.

Mol Cell Biol. 2005 Dec;25(24):11030-4.


Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages.

Zou W, Kim JH, Handidu A, Li X, Kim KI, Yan M, Li J, Zhang DE.

Biochem Biophys Res Commun. 2007 Apr 27;356(1):193-9. Epub 2007 Feb 28.


Ubp43 gene expression is required for normal Isg15 expression and fetal development.

Rempel LA, Austin KJ, Ritchie KJ, Yan M, Shen M, Zhang DE, Henkes LE, Hansen TR.

Reprod Biol Endocrinol. 2007 Mar 26;5:13.


UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE.

J Biol Chem. 2002 Mar 22;277(12):9976-81. Epub 2002 Jan 11.


Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma.

Ruf IK, Houmani JL, Sample JT.

PLoS One. 2009 Jun 24;4(6):e6023. doi: 10.1371/journal.pone.0006023.


Localization of a receptor nonapeptide with a possible role in the binding of the type I interferons.

Eid P, Langer JA, Bailly G, Lejealle R, Guymarho J, Tovey MG.

Eur Cytokine Netw. 2000 Dec;11(4):560-73.

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