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Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA.

EMBO J. 2006 Jun 7;25(11):2605-14. Epub 2006 May 4. Erratum in: EMBO J. 2006 Oct 18;25(20):5036.


Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A.

Shell SM, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano MA, Chazin WJ, Musich PR, Zou Y.

J Biol Chem. 2009 Sep 4;284(36):24213-22. doi: 10.1074/jbc.M109.000745. Epub 2009 Jul 8.


ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.

Wu X, Shell SM, Liu Y, Zou Y.

Oncogene. 2007 Feb 1;26(5):757-64. Epub 2006 Jul 24.


XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase.

Li Z, Musich PR, Serrano MA, Dong Z, Zou Y.

PLoS One. 2011;6(12):e28326. doi: 10.1371/journal.pone.0028326. Epub 2011 Dec 12.


HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.

Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ.

Nat Cell Biol. 2007 Apr;9(4):391-401. Epub 2007 Mar 25.


An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage.

Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, Kaufmann WK.

Mol Cell Biol. 2002 Dec;22(24):8552-61.


Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Zou L, Elledge SJ.

Science. 2003 Jun 6;300(5625):1542-8.


Study of the DNA damage checkpoint using Xenopus egg extracts.

Willis J, DeStephanis D, Patel Y, Gowda V, Yan S.

J Vis Exp. 2012 Nov 5;(69):e4449. doi: 10.3791/4449.


APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110. Epub 2013 Jun 10.


Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.

Matsumoto M, Yaginuma K, Igarashi A, Imura M, Hasegawa M, Iwabuchi K, Date T, Mori T, Ishizaki K, Yamashita K, Inobe M, Matsunaga T.

J Cell Sci. 2007 Mar 15;120(Pt 6):1104-12. Epub 2007 Feb 27.


ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.

Ray A, Blevins C, Wani G, Wani AA.

PLoS One. 2016 Jul 21;11(7):e0159344. doi: 10.1371/journal.pone.0159344. eCollection 2016.


Requirement of MTA1 in ATR-mediated DNA damage checkpoint function.

Li DQ, Ohshiro K, Khan MN, Kumar R.

J Biol Chem. 2010 Jun 25;285(26):19802-12. doi: 10.1074/jbc.M109.085258. Epub 2010 Apr 28.


ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells.

Despras E, Daboussi F, Hyrien O, Marheineke K, Kannouche PL.

Hum Mol Genet. 2010 May 1;19(9):1690-701. doi: 10.1093/hmg/ddq046. Epub 2010 Feb 1.


Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

Kumagai A, Kim SM, Dunphy WG.

J Biol Chem. 2004 Nov 26;279(48):49599-608. Epub 2004 Sep 15.


Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Byun TS, Pacek M, Yee MC, Walter JC, Cimprich KA.

Genes Dev. 2005 May 1;19(9):1040-52. Epub 2005 Apr 15.


Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485. Epub 2009 Oct 14.


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