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NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration.

Conforti L, Fang G, Beirowski B, Wang MS, Sorci L, Asress S, Adalbert R, Silva A, Bridge K, Huang XP, Magni G, Glass JD, Coleman MP.

Cell Death Differ. 2007 Jan;14(1):116-27. Epub 2006 Apr 28.


Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

Yahata N, Yuasa S, Araki T.

J Neurosci. 2009 May 13;29(19):6276-84. doi: 10.1523/JNEUROSCI.4304-08.2009.


Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function.

Jia H, Yan T, Feng Y, Zeng C, Shi X, Zhai Q.

Neurosci Lett. 2007 Feb 8;413(1):46-51. Epub 2006 Dec 15.


Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.

Conforti L, Janeckova L, Wagner D, Mazzola F, Cialabrini L, Di Stefano M, Orsomando G, Magni G, Bendotti C, Smyth N, Coleman M.

FEBS J. 2011 Aug;278(15):2666-79. doi: 10.1111/j.1742-4658.2011.08193.x. Epub 2011 Jun 14.


Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP.

J Neurosci. 2010 Oct 6;30(40):13291-304. doi: 10.1523/JNEUROSCI.1189-10.2010.


Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo.

Sasaki Y, Vohra BP, Baloh RH, Milbrandt J.

J Neurosci. 2009 May 20;29(20):6526-34. doi: 10.1523/JNEUROSCI.1429-09.2009.


Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.

Avery MA, Sheehan AE, Kerr KS, Wang J, Freeman MR.

J Cell Biol. 2009 Feb 23;184(4):501-13. doi: 10.1083/jcb.200808042.


Axon degeneration: Mechanisms and implications of a distinct program from cell death.

Yan T, Feng Y, Zhai Q.

Neurochem Int. 2010 Mar;56(4):529-34. doi: 10.1016/j.neuint.2010.01.013. Epub 2010 Feb 1. Review.


WldS can delay Wallerian degeneration in mice when interaction with valosin-containing protein is weakened.

Beirowski B, Morreale G, Conforti L, Mazzola F, Di Stefano M, Wilbrey A, Babetto E, Janeckova L, Magni G, Coleman MP.

Neuroscience. 2010 Mar 10;166(1):201-11. doi: 10.1016/j.neuroscience.2009.12.024. Epub 2009 Dec 16.


Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1.

Watanabe M, Tsukiyama T, Hatakeyama S.

Neurosci Lett. 2007 Jan 16;411(3):228-32. Epub 2006 Nov 17.


A local mechanism mediates NAD-dependent protection of axon degeneration.

Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z.

J Cell Biol. 2005 Aug 1;170(3):349-55. Epub 2005 Jul 25.


Wld(S), Nmnats and axon degeneration--progress in the past two decades.

Feng Y, Yan T, He Z, Zhai Q.

Protein Cell. 2010 Mar;1(3):237-45. doi: 10.1007/s13238-010-0021-2. Epub 2010 Feb 23. Review.


Maintaining energy homeostasis is an essential component of Wld(S)-mediated axon protection.

Shen H, Hyrc KL, Goldberg MP.

Neurobiol Dis. 2013 Nov;59:69-79. doi: 10.1016/j.nbd.2013.07.007. Epub 2013 Jul 24.


Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG.

Hum Mol Genet. 2013 Apr 15;22(8):1601-14. doi: 10.1093/hmg/ddt009. Epub 2013 Jan 11.


Wallerian degeneration, wld(s), and nmnat.

Coleman MP, Freeman MR.

Annu Rev Neurosci. 2010;33:245-67. doi: 10.1146/annurev-neuro-060909-153248. Review.


The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.

Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW.

Neurobiol Dis. 2011 Apr;42(1):1-8. doi: 10.1016/j.nbd.2010.12.006. Epub 2010 Dec 16.


WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.

Antenor-Dorsey JA, O'Malley KL.

Mol Neurodegener. 2012 Feb 8;7:5. doi: 10.1186/1750-1326-7-5.


Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.

Yan T, Feng Y, Zheng J, Ge X, Zhang Y, Wu D, Zhao J, Zhai Q.

Neurochem Int. 2010 Jan;56(1):101-6. doi: 10.1016/j.neuint.2009.09.007. Epub 2009 Sep 22.


Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.

Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M.

J Cell Biol. 2009 Feb 23;184(4):491-500. doi: 10.1083/jcb.200807175.

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