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Items: 1 to 20 of 303

1.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.

Nature. 2006 Apr 27;440(7088):1208-12.

PMID:
16641999
2.

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
3.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.

Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.

FEBS J. 2005 Nov;272(21):5544-57.

4.

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

Evin G, Canterford LD, Hoke DE, Sharples RA, Culvenor JG, Masters CL.

Biochemistry. 2005 Mar 22;44(11):4332-41.

PMID:
15766262
5.

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.

J Biol Chem. 2003 Jun 20;278(25):22475-81. Epub 2003 Apr 8.

6.

Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.

Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW.

Biochemistry. 2004 Mar 30;43(12):3555-63.

PMID:
15035625
7.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

8.

gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.

J Neurochem. 2005 Nov;95(3):880-90. Epub 2005 Aug 31.

9.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

10.

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.

J Biol Chem. 2005 Jul 22;280(29):27303-9. Epub 2005 May 25.

11.

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.

12.

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C.

J Biol Chem. 2002 Oct 18;277(42):39062-5. Epub 2002 Aug 26.

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16.

PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.

Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.

J Neurochem. 2004 Sep;90(6):1402-13.

17.

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.

Nature. 2000 Jun 8;405(6787):689-94.

PMID:
10864326
18.

Identification of distinct gamma-secretase complexes with different APH-1 variants.

Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H.

J Biol Chem. 2004 Oct 1;279(40):41340-5. Epub 2004 Jul 30.

19.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

20.

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.

Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, Yu G.

J Biol Chem. 2004 Feb 6;279(6):4144-52. Epub 2003 Nov 19.

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