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Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia.

Palomero T, Odom DT, O'Neil J, Ferrando AA, Margolin A, Neuberg DS, Winter SS, Larson RS, Li W, Liu XS, Young RA, Look AT.

Blood. 2006 Aug 1;108(3):986-92. Epub 2006 Apr 18.


Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.

Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CH, Staudt LM, Young RA, Look AT.

Cancer Cell. 2012 Aug 14;22(2):209-21. doi: 10.1016/j.ccr.2012.06.007.


NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia.

Kusy S, Gerby B, Goardon N, Gault N, Ferri F, Gérard D, Armstrong F, Ballerini P, Cayuela JM, Baruchel A, Pflumio F, Roméo PH.

J Exp Med. 2010 Sep 27;207(10):2141-56. doi: 10.1084/jem.20100745. Epub 2010 Sep 20.


Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins.

Hsu HL, Huang L, Tsan JT, Funk W, Wright WE, Hu JS, Kingston RE, Baer R.

Mol Cell Biol. 1994 Feb;14(2):1256-65.


The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia.

Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson CH, von Boehmer H, Young RA, Look AT.

J Exp Med. 2013 Jul 29;210(8):1545-57. doi: 10.1084/jem.20122516. Epub 2013 Jul 15.


TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

O'Neil J, Shank J, Cusson N, Murre C, Kelliher M.

Cancer Cell. 2004 Jun;5(6):587-96.


Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.

Patel B, Kang Y, Cui K, Litt M, Riberio MS, Deng C, Salz T, Casada S, Fu X, Qiu Y, Zhao K, Huang S.

Leukemia. 2014 Feb;28(2):349-61. doi: 10.1038/leu.2013.158. Epub 2013 May 23.


Positive and negative transcriptional control by the TAL1 helix-loop-helix protein.

Hsu HL, Wadman I, Tsan JT, Baer R.

Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5947-51.


The translocation (1;14)(p34;q11) in human T-cell leukemia: chromosome breakage 25 kilobase pairs downstream of the TAL1 protooncogene.

Xia Y, Brown L, Tsan JT, Yang CY, Siciliano MJ, Crist WM, Carroll AJ, Baer R.

Genes Chromosomes Cancer. 1992 Apr;4(3):211-6.


SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression.

Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T.

Nat Immunol. 2000 Aug;1(2):138-44.


SCL: from the origin of hematopoiesis to stem cells and leukemia.

Lécuyer E, Hoang T.

Exp Hematol. 2004 Jan;32(1):11-24. Review.


Antiapoptotic effect of ectopic TAL1/SCL expression in a human leukemic T-cell line.

Bernard M, Delabesse E, Novault S, Hermine O, Macintyre EA.

Cancer Res. 1998 Jun 15;58(12):2680-7.


Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages.

Palii CG, Perez-Iratxeta C, Yao Z, Cao Y, Dai F, Davison J, Atkins H, Allan D, Dilworth FJ, Gentleman R, Tapscott SJ, Brand M.

EMBO J. 2011 Feb 2;30(3):494-509. doi: 10.1038/emboj.2010.342. Epub 2010 Dec 21.


SIL/TAL1 recombination in adult T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma.

Kwong YL, Chan D, Liang R.

Cancer Genet Cytogenet. 1995 Dec;85(2):159-60. No abstract available.


The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.

Robb L, Begley CG.

Bioessays. 1997 Jul;19(7):607-13. Review.


A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.

Draheim KM, Hermance N, Yang Y, Arous E, Calvo J, Kelliher MA.

Oncogene. 2011 Mar 10;30(10):1252-60. doi: 10.1038/onc.2010.495. Epub 2010 Nov 8.


Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.

Gering M, Yamada Y, Rabbitts TH, Patient RK.

Development. 2003 Dec;130(25):6187-99. Epub 2003 Nov 5.


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