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Items: 1 to 20 of 126

1.

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. Epub 2006 Apr 18.

PMID:
16621545
2.

In vitro evidence that hsp90 contains two independent chaperone sites.

Young JC, Schneider C, Hartl FU.

FEBS Lett. 1997 Nov 24;418(1-2):139-43.

3.

Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.

Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.

J Med Chem. 2004 Jul 15;47(15):3865-73.

PMID:
15239664
4.

Structure-based design of 7-carbamate analogs of geldanamycin.

Rastelli G, Tian ZQ, Wang Z, Myles D, Liu Y.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5016-21.

PMID:
16165354
5.

[Heat shock protein 90: novel target for cancer therapy].

Chen Y, Ding J.

Ai Zheng. 2004 Aug;23(8):968-74. Review. Chinese.

PMID:
15301726
6.

[Advances in antitumor activity of the hsp90 inhibitor geldanamycin].

Liao ZY, Zhen YS.

Yao Xue Xue Bao. 2001 Sep;36(9):716-20. Review. Chinese. No abstract available.

PMID:
12580116
7.

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8.

PMID:
14592488
8.

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC.

Bioorg Med Chem. 2004 Oct 15;12(20):5317-29.

PMID:
15388159
9.

Structure and in vivo function of Hsp90.

Pearl LH, Prodromou C.

Curr Opin Struct Biol. 2000 Feb;10(1):46-51. Review.

PMID:
10679459
10.

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.

Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV.

Chem Biol. 2003 Apr;10(4):361-8.

11.

Biotinylated geldanamycin.

Clevenger RC, Raibel JM, Peck AM, Blagg BS.

J Org Chem. 2004 Jun 25;69(13):4375-80.

PMID:
15202892
12.

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. Epub 2006 Jun 22.

PMID:
16797988
13.

Design of quinolinedione-based geldanamycin analogues.

Hargreaves R, David CL, Whitesell L, Skibo EB.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3075-8.

PMID:
12941337
14.

Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions.

Andrus MB, Meredith EL, Simmons BL, Soma Sekhar BB, Hicken EJ.

Org Lett. 2002 Oct 3;4(20):3549-52.

PMID:
12323066
15.

NMR backbone assignment of the N-terminal domain of human HSP90.

Jacobs DM, Langer T, Elshorst B, Saxena K, Fiebig KM, Vogtherr M, Schwalbe H.

J Biomol NMR. 2006;36 Suppl 1:52. Epub 2006 Jul 5. No abstract available.

PMID:
16821127
16.

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.

J Med Chem. 2006 Jul 27;49(15):4606-15.

PMID:
16854066
17.

Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety.

Lee D, Lee K, Cai XF, Dat NT, Boovanahalli SK, Lee M, Shin JC, Kim W, Jeong JK, Lee JS, Lee CH, Lee JH, Hong YS, Lee JJ.

Chembiochem. 2006 Feb;7(2):246-8. No abstract available.

PMID:
16381049
18.

The heat shock protein 90 of Leishmania donovani.

Wiesgigl M, Clos J.

Med Microbiol Immunol. 2001 Nov;190(1-2):27-31.

PMID:
11770104
19.

Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.

Chiosis G, Caldas Lopes E, Solit D.

Curr Opin Investig Drugs. 2006 Jun;7(6):534-41. Review.

PMID:
16784024

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