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Items: 1 to 20 of 127


Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.

Valentine MT, Fordyce PM, Krzysiak TC, Gilbert SP, Block SM.

Nat Cell Biol. 2006 May;8(5):470-6. Epub 2006 Apr 2.


TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.

Balchand SK, Mann BJ, Titus J, Ross JL, Wadsworth P.

J Biol Chem. 2015 Jul 10;290(28):17367-79. doi: 10.1074/jbc.M114.612903. Epub 2015 May 27.


Distinctions between dynamic characteristics of the single EG5 motor protein along neural vs. cancerous microtubules.

Feizabadi MS, Jun Y, Reddy JN.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1630-3. doi: 10.1016/j.bbrc.2016.08.171. Epub 2016 Aug 31.


Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers.

Valentine MT, Block SM.

Biophys J. 2009 Sep 16;97(6):1671-7. doi: 10.1016/j.bpj.2009.07.013.


Microtubule cross-linking triggers the directional motility of kinesin-5.

Kapitein LC, Kwok BH, Weinger JS, Schmidt CF, Kapoor TM, Peterman EJ.

J Cell Biol. 2008 Aug 11;182(3):421-8. doi: 10.1083/jcb.200801145. Epub 2008 Aug 4.


Single-headed mode of kinesin-5.

Kaseda K, Crevel I, Hirose K, Cross RA.

EMBO Rep. 2008 Aug;9(8):761-5. doi: 10.1038/embor.2008.96. Epub 2008 Jun 13.


Mechanistic analysis of the mitotic kinesin Eg5.

Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP.

J Biol Chem. 2004 Sep 10;279(37):38861-70. Epub 2004 Jul 6.


Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.

Krzysiak TC, Grabe M, Gilbert SP.

J Biol Chem. 2008 Jan 25;283(4):2078-87. Epub 2007 Nov 25.


A structural model for monastrol inhibition of dimeric kinesin Eg5.

Krzysiak TC, Wendt T, Sproul LR, Tittmann P, Gross H, Gilbert SP, Hoenger A.

EMBO J. 2006 May 17;25(10):2263-73. Epub 2006 Apr 27.


Kinesin processivity is gated by phosphate release.

Milic B, Andreasson JO, Hancock WO, Block SM.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14136-40. doi: 10.1073/pnas.1410943111. Epub 2014 Sep 2.


Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.

Korneev MJ, Lakämper S, Schmidt CF.

Eur Biophys J. 2007 Jul;36(6):675-81. Epub 2007 Feb 28.


Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

Brier S, Lemaire D, Debonis S, Forest E, Kozielski F.

Biochemistry. 2004 Oct 19;43(41):13072-82.


Kinetic and mechanistic basis of the nonprocessive Kinesin-3 motor NcKin3.

Adio S, Bloemink M, Hartel M, Leier S, Geeves MA, Woehlke G.

J Biol Chem. 2006 Dec 8;281(49):37782-93. Epub 2006 Oct 1.


A processive single-headed motor: kinesin superfamily protein KIF1A.

Okada Y, Hirokawa N.

Science. 1999 Feb 19;283(5405):1152-7.


Monastrol inhibition of the mitotic kinesin Eg5.

Cochran JC, Gatial JE 3rd, Kapoor TM, Gilbert SP.

J Biol Chem. 2005 Apr 1;280(13):12658-67. Epub 2005 Jan 23.


To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.

Valentine MT, Gilbert SP.

Curr Opin Cell Biol. 2007 Feb;19(1):75-81. Epub 2006 Dec 26. Review.


Kinetics and motility of the Eg5 microtubule motor.

Lockhart A, Cross RA.

Biochemistry. 1996 Feb 20;35(7):2365-73.


Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.

Muretta JM, Behnke-Parks WM, Major J, Petersen KJ, Goulet A, Moores CA, Thomas DD, Rosenfeld SS.

J Biol Chem. 2013 Nov 29;288(48):34839-49. doi: 10.1074/jbc.M113.518845. Epub 2013 Oct 21.


Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker.

Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R.

J Biol Chem. 2001 Jul 6;276(27):25496-502. Epub 2001 Apr 27.


Loading direction regulates the affinity of ADP for kinesin.

Uemura S, Ishiwata S.

Nat Struct Biol. 2003 Apr;10(4):308-11.


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