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Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.

Arnold JS, Braunstein EM, Ohyama T, Groves AK, Adams JC, Brown MC, Morrow BE.

Hum Mol Genet. 2006 May 15;15(10):1629-39. Epub 2006 Apr 6.


Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.

Moraes F, Nóvoa A, Jerome-Majewska LA, Papaioannou VE, Mallo M.

Mech Dev. 2005 Feb;122(2):199-212.


Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis.

Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE.

BMC Dev Biol. 2009 May 29;9:31. doi: 10.1186/1471-213X-9-31.


Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations.

Arnold JS, Werling U, Braunstein EM, Liao J, Nowotschin S, Edelmann W, Hebert JM, Morrow BE.

Development. 2006 Mar;133(5):977-87. Epub 2006 Feb 1.


Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development.

Monks DC, Morrow BE.

Dev Dyn. 2012 Mar;241(3):563-73. doi: 10.1002/dvdy.23731. Epub 2012 Feb 1.


Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice.

Freyer L, Nowotschin S, Pirity MK, Baldini A, Morrow BE.

BMC Dev Biol. 2013 Aug 23;13:33. doi: 10.1186/1471-213X-13-33.


TBX1 is required for inner ear morphogenesis.

Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E.

Hum Mol Genet. 2003 Aug 15;12(16):2041-8.


Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation.

Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC.

J Assoc Res Otolaryngol. 2008 Mar;9(1):33-43. doi: 10.1007/s10162-008-0110-6. Epub 2008 Jan 30.


Dual embryonic origin of the mammalian otic vesicle forming the inner ear.

Freyer L, Aggarwal V, Morrow BE.

Development. 2011 Dec;138(24):5403-14. doi: 10.1242/dev.069849.


Tbx1 and Jag1 act in concert to modulate the fate of neurosensory cells of the mouse otic vesicle.

Macchiarulo S, Morrow BE.

Biol Open. 2017 Oct 15;6(10):1472-1482. doi: 10.1242/bio.027359.


Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.

Aggarwal VS, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, Shanske A, Campione M, Morrow BE.

Hum Mol Genet. 2006 Nov 1;15(21):3219-28. Epub 2006 Sep 25.


Suppression of neural fate and control of inner ear morphogenesis by Tbx1.

Raft S, Nowotschin S, Liao J, Morrow BE.

Development. 2004 Apr;131(8):1801-12. Epub 2004 Mar 17.


Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1.

Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ.

Dev Biol. 2005 Sep 15;285(2):554-69.


Pax3 function is required specifically for inner ear structures with melanogenic fates.

Kim H, Ankamreddy H, Lee DJ, Kong KA, Ko HW, Kim MH, Bok J.

Biochem Biophys Res Commun. 2014 Mar 14;445(3):608-14. doi: 10.1016/j.bbrc.2014.02.047. Epub 2014 Feb 21.


Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.

Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE.

PLoS Genet. 2017 Mar 27;13(3):e1006687. doi: 10.1371/journal.pgen.1006687. eCollection 2017 Mar.


Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse.

Choi M, Klingensmith J.

PLoS Genet. 2009 Feb;5(2):e1000395. doi: 10.1371/journal.pgen.1000395. Epub 2009 Feb 27.


Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.

Paylor R, Glaser B, Mupo A, Ataliotis P, Spencer C, Sobotka A, Sparks C, Choi CH, Oghalai J, Curran S, Murphy KC, Monks S, Williams N, O'Donovan MC, Owen MJ, Scambler PJ, Lindsay E.

Proc Natl Acad Sci U S A. 2006 May 16;103(20):7729-34. Epub 2006 May 9.


The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning.

Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, Nilsson M.

Hum Mol Genet. 2007 Feb 1;16(3):276-85. Epub 2006 Dec 12.


Otic mesenchyme expression of Cre recombinase directed by the inner ear enhancer of the Brn4/Pou3f4 gene.

Ahn KJ, Passero F Jr, Crenshaw EB 3rd.

Genesis. 2009 Mar;47(3):137-41. doi: 10.1002/dvg.20454.


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