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Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity.

Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, Lillie EO, Ziegler MG, Smith DW, Schork NJ, Brown JH, O'Connor DT.

Hypertension. 2006 May;47(5):937-47. Epub 2006 Apr 3.


Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo.

Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton BA, Mahata SK, O'Connor DT.

J Am Coll Cardiol. 2009 Sep 1;54(10):944-54. doi: 10.1016/j.jacc.2009.05.035. Erratum in: J Am Coll Cardiol. 2009 Oct 6;54(15):1482.


Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.

Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT.

J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. Erratum in: J Am Coll Cardiol. 2012 Nov 20;60(21):2261.


Polymorphisms and haplotype of ROCK2 associate with high altitude essential hypertension in native high altitude Ladakhi Indian population: a preliminary study.

Pandey P, Mohammad G, Singh Y, Pasha MA.

Clin Exp Hypertens. 2016;38(2):238-44. doi: 10.3109/10641963.2015.1081231. Epub 2016 Jan 28.


Human heart rate: heritability of resting and stress values in twin pairs, and influence of genetic variation in the adrenergic pathway at a microribonucleic acid (microrna) motif in the 3'-UTR of cytochrome b561 [corrected].

Zhang K, Deacon DC, Rao F, Schork AJ, Fung MM, Waalen J, Schork NJ, Nievergelt CM, Chi NC, O'Connor DT.

J Am Coll Cardiol. 2014 Feb 4;63(4):358-68. doi: 10.1016/j.jacc.2013.09.025. Epub 2013 Oct 16. Erratum in: J Am Coll Cardiol. 2014 Mar 25;63(11):1122.


Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.

Zhang L, Rao F, Wessel J, Kennedy BP, Rana BK, Taupenot L, Lillie EO, Cockburn M, Schork NJ, Ziegler MG, O'Connor DT.

Physiol Genomics. 2004 Nov 17;19(3):277-91. Epub 2004 Sep 14.


C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci.

Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT.

J Hypertens. 2007 Feb;25(2):329-43.


Genetic implication of a novel thiamine transporter in human hypertension.

Zhang K, Huentelman MJ, Rao F, Sun EI, Corneveaux JJ, Schork AJ, Wei Z, Waalen J, Miramontes-Gonzalez JP, Hightower CM, Maihofer AX, Mahata M, Pastinen T, Ehret GB; International Consortium for Blood Pressure Genome-Wide Association Studies, Schork NJ, Eskin E, Nievergelt CM, Saier MH Jr, O'Connor DT.

J Am Coll Cardiol. 2014 Apr 22;63(15):1542-55. doi: 10.1016/j.jacc.2014.01.007. Epub 2014 Feb 5.


Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton BA, Mahata SK, Taupenot L, O'Connor DT.

J Am Coll Cardiol. 2008 Oct 28;52(18):1468-81. doi: 10.1016/j.jacc.2008.07.047.


STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men.

Donner KM, Hiltunen TP, Hannila-Handelberg T, Suonsyrjä T, Kontula K.

Hypertens Res. 2012 Jan;35(1):107-14. doi: 10.1038/hr.2011.166. Epub 2011 Oct 13.


Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects.

Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, Snieder H, Dong Y.

Hypertension. 2007 Jan;49(1):107-12. Epub 2006 Nov 20.


Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample.

Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS.

Hypertension. 2007 Apr;49(4):846-56. Epub 2007 Feb 12.


Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide.

Schwartz GL, Turner ST, Chapman AB, Boerwinkle E.

Kidney Int. 2002 Nov;62(5):1718-23.


Adrenergic polymorphism and the human stress response.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.

Ann N Y Acad Sci. 2008 Dec;1148:282-96. doi: 10.1196/annals.1410.085.


Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins.

Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton BA, Mahata SK, O'Connor DT.

Am J Hypertens. 2012 Jan;25(1):29-40. doi: 10.1038/ajh.2011.163. Epub 2011 Sep 15.


Genetic influences on blood pressure response to the cold pressor test: results from the Heredity and Phenotype Intervention Heart Study.

Roy-Gagnon MH, Weir MR, Sorkin JD, Ryan KA, Sack PA, Hines S, Bielak LF, Peyser PA, Post W, Mitchell BD, Shuldiner AR, Douglas JA.

J Hypertens. 2008 Apr;26(4):729-36. doi: 10.1097/HJH.0b013e3282f524b4.


Autonomic and hemodynamic origins of pre-hypertension: central role of heredity.

Davis JT, Rao F, Naqshbandi D, Fung MM, Zhang K, Schork AJ, Nievergelt CM, Ziegler MG, O'Connor DT.

J Am Coll Cardiol. 2012 Jun 12;59(24):2206-16. doi: 10.1016/j.jacc.2012.02.040.


Expression of altered alpha2-adrenergic phenotypic traits in normotensive humans at genetic risk of hereditary (essential) hypertension.

Dao TT, Kailasam MT, Parmer RJ, Le HV, Le Verge R, Kennedy BP, Ziegler G, Insel PA, Wright FA, O'Connor DT.

J Hypertens. 1998 Jun;16(6):779-92.


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