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Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.

Boisvert WA, Rose DM, Johnson KA, Fuentes ME, Lira SA, Curtiss LK, Terkeltaub RA.

Am J Pathol. 2006 Apr;168(4):1385-95.


GRO-alpha and CXCR2 in the human fetal brain and multiple sclerosis lesions.

Filipovic R, Jakovcevski I, Zecevic N.

Dev Neurosci. 2003 Mar-Aug;25(2-4):279-90.


Combinatorial model of chemokine involvement in glomerular monocyte recruitment: role of CXC chemokine receptor 2 in infiltration during nephrotoxic nephritis.

Zernecke A, Weber KS, Erwig LP, Kluth DC, Schröppel B, Rees AJ, Weber C.

J Immunol. 2001 May 1;166(9):5755-62.


CXCR2 is critical to hyperoxia-induced lung injury.

Sue RD, Belperio JA, Burdick MD, Murray LA, Xue YY, Dy MC, Kwon JJ, Keane MP, Strieter RM.

J Immunol. 2004 Mar 15;172(6):3860-8.


Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2.

Kershaw MH, Wang G, Westwood JA, Pachynski RK, Tiffany HL, Marincola FM, Wang E, Young HA, Murphy PM, Hwu P.

Hum Gene Ther. 2002 Nov 1;13(16):1971-80.


The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium.

Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, Jung S, Littman DR, Ley K.

J Clin Invest. 2001 Nov;108(9):1307-14.


Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.

Hu L, Boesten LS, May P, Herz J, Bovenschen N, Huisman MV, Berbée JF, Havekes LM, van Vlijmen BJ, Tamsma JT.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2710-5. Epub 2006 Oct 12.


Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF.

Circulation. 2007 Sep 18;116(12):1404-12. Epub 2007 Aug 27.


High expression of chemokines Gro-alpha (CXCL-1), IL-8 (CXCL-8), and MCP-1 (CCL-2) in inflamed human corneas in vivo.

Spandau UH, Toksoy A, Verhaart S, Gillitzer R, Kruse FE.

Arch Ophthalmol. 2003 Jun;121(6):825-31.


A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5.

Vieira SM, Lemos HP, Grespan R, Napimoga MH, Dal-Secco D, Freitas A, Cunha TM, Verri WA Jr, Souza-Junior DA, Jamur MC, Fernandes KS, Oliver C, Silva JS, Teixeira MM, Cunha FQ.

Br J Pharmacol. 2009 Oct;158(3):779-89. doi: 10.1111/j.1476-5381.2009.00367.x. Epub 2009 Aug 20.


Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice.

Dol F, Martin G, Staels B, Mares AM, Cazaubon C, Nisato D, Bidouard JP, Janiak P, Schaeffer P, Herbert JM.

J Cardiovasc Pharmacol. 2001 Sep;38(3):395-405.


Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice.

Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF.

J Biol Chem. 2000 Aug 25;275(34):26293-9.


A novel RANTES antagonist prevents progression of established atherosclerotic lesions in mice.

Braunersreuther V, Steffens S, Arnaud C, Pelli G, Burger F, Proudfoot A, Mach F.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1090-6. doi: 10.1161/ATVBAHA.108.165423. Epub 2008 Apr 3.


Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice.

Lewis P, Stefanovic N, Pete J, Calkin AC, Giunti S, Thallas-Bonke V, Jandeleit-Dahm KA, Allen TJ, Kola I, Cooper ME, de Haan JB.

Circulation. 2007 Apr 24;115(16):2178-87. Epub 2007 Apr 9.


Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice.

Van Eck M, Singaraja RR, Ye D, Hildebrand RB, James ER, Hayden MR, Van Berkel TJ.

Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):929-34. Epub 2006 Feb 2.

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