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In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

Kissler S, Stern P, Takahashi K, Hunter K, Peterson LB, Wicker LS.

Nat Genet. 2006 Apr;38(4):479-83. Epub 2006 Mar 19.


Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.

Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB.

J Immunol. 2004 Jul 1;173(1):164-73.


Promoter polymorphism of SLC11A1 (formerly NRAMP1) confers susceptibility to autoimmune type 1 diabetes mellitus in Japanese.

Takahashi K, Satoh J, Kojima Y, Negoro K, Hirai M, Hinokio Y, Kinouchi Y, Suzuki S, Matsuura N, Shimosegawa T, Oka Y.

Tissue Antigens. 2004 Mar;63(3):231-6.


Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.

Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG.

J Rheumatol. 2000 Aug;27(8):1896-904.


Sex-specific effect of insulin-dependent diabetes 4 on regulation of diabetes pathogenesis in the nonobese diabetic mouse.

Ivakine EA, Fox CJ, Paterson AD, Mortin-Toth SM, Canty A, Walton DS, Aleksa K, Ito S, Danska JS.

J Immunol. 2005 Jun 1;174(11):7129-40.


Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region.

Colucci F, Bergman ML, Penha-Gonçalves C, Cilio CM, Holmberg D.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8670-4.


Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes.

Lin X, Hamilton-Williams EE, Rainbow DB, Hunter KM, Dai YD, Cheung J, Peterson LB, Wicker LS, Sherman LA.

J Immunol. 2013 Apr 1;190(7):3109-20. doi: 10.4049/jimmunol.1203422. Epub 2013 Feb 20.


The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis.

Greve B, Vijayakrishnan L, Kubal A, Sobel RA, Peterson LB, Wicker LS, Kuchroo VK.

J Immunol. 2004 Jul 1;173(1):157-63.


Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.

Ivakine EA, Gulban OM, Mortin-Toth SM, Wankiewicz E, Scott C, Spurrell D, Canty A, Danska JS.

J Immunol. 2006 Mar 1;176(5):2976-90.


Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.

Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ.

Diabetes. 2001 Dec;50(12):2874-8.


The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.

Ivakine EA, Mortin-Toth SM, Gulban OM, Valova A, Canty A, Scott C, Danska JS.

Diabetes. 2006 Dec;55(12):3611-9.


NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB.

Diabetes. 2000 Oct;49(10):1744-7.


Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.

Ikegami H, Fujisawa T, Makino S, Ogihara T.

Ann N Y Acad Sci. 2003 Nov;1005:196-204.


Insulin-dependent diabetes loci Idd5 and Idd9 increase sensitivity to experimental autoimmune encephalomyelitis.

Mayo S, Kohler W, Kumar V, Quinn A.

Clin Immunol. 2006 Feb-Mar;118(2-3):219-28. Epub 2005 Nov 21.


Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice.

Yamada K, Ikegami H, Kawaguchi Y, Fujisawa T, Hotta M, Ueda H, Shintani M, Nojima K, Kawabata Y, Ono M, Nishino M, Itoi M, Babaya N, Shibata M, Makino S, Ogihara T.

Endocr J. 2001 Apr;48(2):241-7.


A 20-Mb region of chromosome 4 controls TNF-alpha-mediated CD8+ T cell aggression toward beta cells in type 1 diabetes.

Chamberlain G, Wållberg M, Rainbow D, Hunter K, Wicker LS, Green EA.

J Immunol. 2006 Oct 15;177(8):5105-14.


Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg).

Blackwell JM, Searle S.

Immunol Lett. 1999 Jan;65(1-2):73-80.


Evidence of association with type 1 diabetes in the SLC11A1 gene region.

Yang JH, Downes K, Howson JM, Nutland S, Stevens HE, Walker NM, Todd JA.

BMC Med Genet. 2011 Apr 27;12:59. doi: 10.1186/1471-2350-12-59.

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