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ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts.

Innes CL, Heinloth AN, Flores KG, Sieber SO, Deming PB, Bushel PR, Kaufmann WK, Paules RS.

Mol Cancer Res. 2006 Mar;4(3):197-207.


Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells.

Momcilović O, Choi S, Varum S, Bakkenist C, Schatten G, Navara C.

Stem Cells. 2009 Aug;27(8):1822-35. doi: 10.1002/stem.123.


Ataxia telangiectasia-mutated dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts.

Zhou T, Chou J, Zhou Y, Simpson DA, Cao F, Bushel PR, Paules RS, Kaufmann WK.

Mol Cancer Res. 2007 Aug;5(8):813-22.


Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.

Gueven N, Keating KE, Chen P, Fukao T, Khanna KK, Watters D, Rodemann PH, Lavin MF.

J Biol Chem. 2001 Mar 23;276(12):8884-91. Epub 2000 Nov 15.


Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation.

Xu B, Kim ST, Lim DS, Kastan MB.

Mol Cell Biol. 2002 Feb;22(4):1049-59.


ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.

Lavin MF, Khanna KK.

Int J Radiat Biol. 1999 Oct;75(10):1201-14. Review.


Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia.

Ziv S, Brenner O, Amariglio N, Smorodinsky NI, Galron R, Carrion DV, Zhang W, Sharma GG, Pandita RK, Agarwal M, Elkon R, Katzin N, Bar-Am I, Pandita TK, Kucherlapati R, Rechavi G, Shiloh Y, Barzilai A.

Hum Mol Genet. 2005 Oct 1;14(19):2929-43. Epub 2005 Sep 8.


p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts.

Cao F, Zhou T, Simpson D, Zhou Y, Boyer J, Chen B, Jin T, Cordeiro-Stone M, Kaufmann W.

Toxicol Appl Pharmacol. 2007 Jan 15;218(2):174-85. Epub 2006 Nov 11.


Ionizing radiation activates the ATM kinase throughout the cell cycle.

Pandita TK, Lieberman HB, Lim DS, Dhar S, Zheng W, Taya Y, Kastan MB.

Oncogene. 2000 Mar 9;19(11):1386-91.


The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts.

Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS.

J Biol Chem. 2001 Jun 15;276(24):21951-9. Epub 2001 Apr 4.


p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.

Prodosmo A, De Amicis A, Nisticò C, Gabriele M, Di Rocco G, Monteonofrio L, Piane M, Cundari E, Chessa L, Soddu S.

J Clin Invest. 2013 Mar;123(3):1335-42. doi: 10.1172/JCI67289. Epub 2013 Feb 1.


Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.

Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF.

Cancer Res. 2006 Mar 15;66(6):2907-12.


ATM-dependent and -independent gene expression changes in response to oxidative stress, gamma irradiation, and UV irradiation.

Heinloth AN, Shackelford RE, Innes CL, Bennett L, Li L, Amin RP, Sieber SO, Flores KG, Bushel PR, Paules RS.

Radiat Res. 2003 Sep;160(3):273-90.


Ataxia telangiectasia and Rad3-related overexpressing cancer cells induce prolonged G₂ arrest and develop resistance to ionizing radiation.

Kim YM, Lee YM, Park SY, Pyo H.

DNA Cell Biol. 2011 Apr;30(4):219-27. doi: 10.1089/dna.2010.1141. Epub 2011 Feb 7.


Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.

Mao JH, Wu D, DelRosario R, Castellanos A, Balmain A, Perez-Losada J.

Oncogene. 2008 Nov 20;27(51):6596-600. doi: 10.1038/onc.2008.280. Epub 2008 Aug 4.


Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity.

White JS, Choi S, Bakkenist CJ.

Cell Cycle. 2008 May 1;7(9):1277-84. Epub 2008 Mar 18.


Enhanced radiation-mediated cell killing of human cervical cancer cells by small interference RNA silencing of ataxia telangiectasia-mutated protein.

Li W, Jian W, Xiaoping X, Yingfeng L, Tao X, Xiaoyan X.

Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1620-30.


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