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Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM.

Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4463-8. Epub 2006 Mar 13.


Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer.

Zhan Y, Modi N, Stewart AM, Hieronimus RI, Liu J, Gutmann DH, Chadee DN.

Oncogene. 2011 Feb 17;30(7):781-9. doi: 10.1038/onc.2010.453. Epub 2010 Oct 4.


A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.

Chadee DN, Kyriakis JM.

Cell Cycle. 2004 Oct;3(10):1227-9. Epub 2004 Oct 19.


MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.

Chadee DN, Kyriakis JM.

Nat Cell Biol. 2004 Aug;6(8):770-6. Epub 2004 Jul 18.


Regulation and role of Raf-1/B-Raf heterodimerization.

Rushworth LK, Hindley AD, O'Neill E, Kolch W.

Mol Cell Biol. 2006 Mar;26(6):2262-72.


RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells.

Fan F, Feng L, He J, Wang X, Jiang X, Zhang Y, Wang Z, Chen Y.

Carcinogenesis. 2008 Jun;29(6):1157-63. doi: 10.1093/carcin/bgn119. Epub 2008 May 29.


Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype.

Yamaguchi T, Wallace DP, Magenheimer BS, Hempson SJ, Grantham JJ, Calvet JP.

J Biol Chem. 2004 Sep 24;279(39):40419-30. Epub 2004 Jul 19.


Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.


Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation.

Hecquet C, Lefevre G, Valtink M, Engelmann K, Mascarelli F.

Invest Ophthalmol Vis Sci. 2002 Sep;43(9):3091-8.


Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.

Ritt DA, Monson DM, Specht SI, Morrison DK.

Mol Cell Biol. 2010 Feb;30(3):806-19. doi: 10.1128/MCB.00569-09. Epub 2009 Nov 23.


B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis.

Sobczak I, Galabova-Kovacs G, Sadzak I, Kren A, Christofori G, Baccarini M.

Oncogene. 2008 Aug 14;27(35):4779-87. doi: 10.1038/onc.2008.128. Epub 2008 May 19.


ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma.

Cohen JD, Gard JM, Nagle RB, Dietrich JD, Monks TJ, Lau SS.

Toxicol Sci. 2011 Nov;124(1):75-87. doi: 10.1093/toxsci/kfr203. Epub 2011 Aug 2.


Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.

Nagao S, Yamaguchi T, Kusaka M, Maser RL, Takahashi H, Cowley BD, Grantham JJ.

Kidney Int. 2003 Feb;63(2):427-37.


Essential role of B-Raf in ERK activation during extraembryonic development.

Galabova-Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen AP, Silva A, Baccarini M.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1325-30. Epub 2006 Jan 23.

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