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Items: 1 to 20 of 87

1.

Efficient characterization of use-dependent ion channel blockers by real-time monitoring of channel state.

Tao H, Guia A, Xie B, Santaana D, Manalo G, Xu J, Ghetti A.

Assay Drug Dev Technol. 2006 Feb;4(1):57-64.

PMID:
16506889
2.

A cell-sparing electric field stimulation technique for high-throughput screening of voltage-gated ion channels.

Bugianesi RM, Augustine PR, Azer K, Dufresne C, Herrington J, Kath GS, McManus OB, Napolitano CS, Rush A, Sachs J, Simpson N, Wismer MK, Kaczorowski GJ, Slaughter RS.

Assay Drug Dev Technol. 2006 Feb;4(1):21-35.

PMID:
16506886
3.

Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes.

Felix JP, Williams BS, Priest BT, Brochu RM, Dick IE, Warren VA, Yan L, Slaughter RS, Kaczorowski GJ, Smith MM, Garcia ML.

Assay Drug Dev Technol. 2004 Jun;2(3):260-8.

PMID:
15285907
4.

State-dependent trapping of flecainide in the cardiac sodium channel.

Ramos E, O'leary ME.

J Physiol. 2004 Oct 1;560(Pt 1):37-49. Epub 2004 Jul 22.

5.

Population patch clamp improves data consistency and success rates in the measurement of ionic currents.

Finkel A, Wittel A, Yang N, Handran S, Hughes J, Costantin J.

J Biomol Screen. 2006 Aug;11(5):488-96. Epub 2006 Jun 7.

PMID:
16760372
6.
7.

Validation of a patch clamp screening protocol that simultaneously measures compound activity in multiple states of the voltage-gated sodium channel Nav1.2.

Liu Y, Beck EJ, Flores CM.

Assay Drug Dev Technol. 2011 Dec;9(6):628-34. doi: 10.1089/adt.2011.0375. Epub 2011 Jun 15.

PMID:
21675872
8.

Characterization of voltage-gated sodium-channel blockers by electrical stimulation and fluorescence detection of membrane potential.

Huang CJ, Harootunian A, Maher MP, Quan C, Raj CD, McCormack K, Numann R, Negulescu PA, González JE.

Nat Biotechnol. 2006 Apr;24(4):439-46. Epub 2006 Mar 19.

PMID:
16550174
9.

Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes.

Leipold E, Borges A, Heinemann SH.

J Gen Physiol. 2012 Apr;139(4):305-19. doi: 10.1085/jgp.201110720.

10.

Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis.

Randall A, McNaughton N, Green P.

Pharmacol Res. 2006 Aug;54(2):118-28. Epub 2006 Mar 24.

PMID:
16675265
11.

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity.

Sheets PL, Jackson JO 2nd, Waxman SG, Dib-Hajj SD, Cummins TR.

J Physiol. 2007 Jun 15;581(Pt 3):1019-31. Epub 2007 Apr 12.

12.

Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.

Williams BS, Felix JP, Priest BT, Brochu RM, Dai K, Hoyt SB, London C, Tang YS, Duffy JL, Parsons WH, Kaczorowski GJ, Garcia ML.

Biochemistry. 2007 Dec 18;46(50):14693-703. Epub 2007 Nov 21.

PMID:
18027973
13.

Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine.

Sheets PL, Heers C, Stoehr T, Cummins TR.

J Pharmacol Exp Ther. 2008 Jul;326(1):89-99. doi: 10.1124/jpet.107.133413. Epub 2008 Mar 31.

14.
15.

Gating behaviour of sodium currents in adult mouse muscle recorded with an improved two-electrode voltage clamp.

Fu Y, Struyk A, Markin V, Cannon S.

J Physiol. 2011 Feb 1;589(Pt 3):525-46. doi: 10.1113/jphysiol.2010.199430. Epub 2010 Dec 6.

16.
17.

Role of the local anesthetic receptor in the state-dependent inhibition of voltage-gated sodium channels by the insecticide metaflumizone.

von Stein RT, Soderlund DM.

Mol Pharmacol. 2012 Mar;81(3):366-74. doi: 10.1124/mol.111.075283. Epub 2011 Nov 29.

18.
19.

Automated electrophysiology in drug discovery.

Priest BT, Swensen AM, McManus OB.

Curr Pharm Des. 2007;13(23):2325-37. Review.

PMID:
17692004
20.

Vinpocetine is a potent blocker of rat NaV1.8 tetrodotoxin-resistant sodium channels.

Zhou X, Dong XW, Crona J, Maguire M, Priestley T.

J Pharmacol Exp Ther. 2003 Aug;306(2):498-504. Epub 2003 May 1.

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