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Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes.

Nilsson R, Ahmad F, Swärd K, Andersson U, Weston M, Manganiello V, Degerman E.

Cell Signal. 2006 Oct;18(10):1713-21. Epub 2006 Feb 28.


Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the beta3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes.

Ahmad F, Lindh R, Tang Y, Ruishalme I, Ost A, Sahachartsiri B, Strålfors P, Degerman E, Manganiello VC.

Biochem J. 2009 Dec 10;424(3):399-410. doi: 10.1042/BJ20090842.


Phosphodiesterase 3B is localized in caveolae and smooth ER in mouse hepatocytes and is important in the regulation of glucose and lipid metabolism.

Berger K, Lindh R, Wierup N, Zmuda-Trzebiatowska E, Lindqvist A, Manganiello VC, Degerman E.

PLoS One. 2009;4(3):e4671. doi: 10.1371/journal.pone.0004671. Epub 2009 Mar 5.


A newly identified 50 kDa protein, which is associated with phosphodiesterase 3B, is phosphorylated by insulin in rat adipocytes.

Onuma H, Osawa H, Ogura T, Tanabe F, Nishida W, Makino H.

Biochem Biophys Res Commun. 2005 Nov 25;337(3):976-82. Epub 2005 Oct 3.


Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor alpha and cAMP.

Rahn Landström T, Mei J, Karlsson M, Manganiello V, Degerman E.

Biochem J. 2000 Mar 1;346 Pt 2:337-43.


Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice.

Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC.

J Clin Invest. 2006 Dec;116(12):3240-51.


Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B.

Degerman E, Landström TR, Wijkander J, Holst LS, Ahmad F, Belfrage P, Manganiello V.

Methods. 1998 Jan;14(1):43-53.


Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes.

Zmuda-Trzebiatowska E, Oknianska A, Manganiello V, Degerman E.

Cell Signal. 2006 Mar;18(3):382-90. Epub 2005 Jun 14.


Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice.

Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Terauchi Y, Kadowaki T, Makino H.

Diabetes Res Clin Pract. 2002 Nov;58(2):79-85.


Early and rapid development of insulin resistance, islet dysfunction and glucose intolerance after high-fat feeding in mice overexpressing phosphodiesterase 3B.

Walz HA, Härndahl L, Wierup N, Zmuda-Trzebiatowska E, Svennelid F, Manganiello VC, Ploug T, Sundler F, Degerman E, Ahrén B, Holst LS.

J Endocrinol. 2006 Jun;189(3):629-41.


Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.

Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS.

Cell Signal. 2007 Jul;19(7):1505-13. Epub 2007 Feb 12.


Hexose transporters GLUT1 and GLUT3 are colocalized with hexokinase I in caveolae microdomains of rat spermatogenic cells.

Rauch MC, Ocampo ME, Bohle J, Amthauer R, Yáñez AJ, Rodríguez-Gil JE, Slebe JC, Reyes JG, Concha II.

J Cell Physiol. 2006 May;207(2):397-406.


Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein.

Onuma H, Osawa H, Yamada K, Ogura T, Tanabe F, Granner DK, Makino H.

Diabetes. 2002 Dec;51(12):3362-7.


Membrane localization of cyclic nucleotide phosphodiesterase 3 (PDE3). Two N-terminal domains are required for the efficient targeting to, and association of, PDE3 with endoplasmic reticulum.

Shakur Y, Takeda K, Kenan Y, Yu ZX, Rena G, Brandt D, Houslay MD, Degerman E, Ferrans VJ, Manganiello VC.

J Biol Chem. 2000 Dec 8;275(49):38749-61.


Differential function of the alpha2A-adrenoceptor and Phosphodiesterase-3B in human adipocytes of different origin.

Dicker A, Kaaman M, van Harmelen V, Aström G, Blanc KL, Rydén M.

Int J Obes (Lond). 2005 Dec;29(12):1413-21.


Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin.

Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahrén B, Manganiello VC, Renström E, Holst LS.

J Biol Chem. 2002 Oct 4;277(40):37446-55. Epub 2002 Aug 6.

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