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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.

Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, Bellefroid E, Marine JC.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3232-7. Epub 2006 Feb 21.


Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.

Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3226-31. Epub 2006 Feb 21.


Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.

Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G.

Cell Death Differ. 2006 Jun;13(6):927-34. Review. No abstract available.


Mouse models of Mdm2 and Mdm4 and their clinical implications.

Xiong S.

Chin J Cancer. 2013 Jul;32(7):371-5. doi: 10.5732/cjc.012.10286. Epub 2013 Jan 18. Review.


A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM.

Cancer Cell. 2006 Apr;9(4):273-85.


Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability.

Pant V, Xiong S, Iwakuma T, Quintás-Cardama A, Lozano G.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11995-2000. doi: 10.1073/pnas.1102241108. Epub 2011 Jul 5.


Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.

Yang H, Zheng Z, Zhao LY, Li Q, Liao D.

Cell Cycle. 2012 Feb 1;11(3):582-93. doi: 10.4161/cc.11.3.19052. Epub 2012 Feb 1.


Distinct roles of Mdm2 and Mdm4 in red cell production.

Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC.

Blood. 2007 Mar 15;109(6):2630-3. Epub 2006 Nov 14.


Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G.

Mol Cell Biol. 2006 Jan;26(1):192-8.


Mdm2 and Mdm4 loss regulates distinct p53 activities.

Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G.

Mol Cancer Res. 2008 Jun;6(6):947-54. doi: 10.1158/1541-7786.MCR-07-2079.


Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo.

De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, Haigh JJ, Marine JC.

Mol Cell Biol. 2010 Nov;30(22):5394-405. doi: 10.1128/MCB.00330-10. Epub 2010 Sep 20.


Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.

Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G.

Nat Genet. 2001 Sep;29(1):92-5.


Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.

Zhang Q, He X, Chen L, Zhang C, Gao X, Yang Z, Liu G.

J Pathol. 2012 Nov;228(3):416-28. doi: 10.1002/path.4077. Epub 2012 Sep 28.


Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.

Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G.

Oncogene. 2004 Oct 7;23(46):7644-50.


Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.

Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G.

Mol Cell Biol. 2007 Aug;27(15):5479-85. Epub 2007 May 25.


MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation.

Qi DL, Cobrinik D.

Oncogene. 2017 Mar 30;36(13):1760-1769. doi: 10.1038/onc.2016.350. Epub 2016 Oct 17.


MDM4 enhances p53 stability by promoting an active conformation of the protein upon DNA damage.

Di Conza G, Mancini F, Buttarelli M, Pontecorvi A, Trimarchi F, Moretti F.

Cell Cycle. 2012 Feb 15;11(4):749-60. doi: 10.4161/cc.11.4.19208.


Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN.

Oncogene. 2005 Nov 24;24(53):7935-40.


The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury.

Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Marine JC, Puttagunta R, Di Giovanni S.

Brain. 2015 Jul;138(Pt 7):1843-62. doi: 10.1093/brain/awv125. Epub 2015 May 16. Erratum in: Brain. 2016 Jan;139(Pt 1):e7. Magali, Cucchiarini [corrected to Cucchiarini, Magali].


Validation of MdmX as a therapeutic target for reactivating p53 in tumors.

Garcia D, Warr MR, Martins CP, Brown Swigart L, Passegué E, Evan GI.

Genes Dev. 2011 Aug 15;25(16):1746-57. doi: 10.1101/gad.16722111.

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