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Items: 1 to 20 of 86

1.

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets.

Birmingham A, Anderson EM, Reynolds A, Ilsley-Tyree D, Leake D, Fedorov Y, Baskerville S, Maksimova E, Robinson K, Karpilow J, Marshall WS, Khvorova A.

Nat Methods. 2006 Mar;3(3):199-204. Erratum in: Nat Methods. 2007 Jun;4(6):533.

PMID:
16489337
2.
3.

Experimental validation of the importance of seed complement frequency to siRNA specificity.

Anderson EM, Birmingham A, Baskerville S, Reynolds A, Maksimova E, Leake D, Fedorov Y, Karpilow J, Khvorova A.

RNA. 2008 May;14(5):853-61. doi: 10.1261/rna.704708. Epub 2008 Mar 26.

4.

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

Sun X, Rogoff HA, Li CJ.

Nat Biotechnol. 2008 Dec;26(12):1379-82. doi: 10.1038/nbt.1512. Epub 2008 Nov 23. Erratum in: Nat Biotechnol. 2009 Feb;27(2):205.

PMID:
19029911
5.

Expression profiling reveals off-target gene regulation by RNAi.

Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS.

Nat Biotechnol. 2003 Jun;21(6):635-7. Epub 2003 May 18.

PMID:
12754523
6.

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites.

Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z.

Nucleic Acids Res. 2005 Mar 21;33(5):1671-7. Print 2005. Erratum in: Nucleic Acids Res. 2005;33(11):3698.

7.

Confirming specificity of RNAi in mammalian cells.

Lassus P, Rodriguez J, Lazebnik Y.

Sci STKE. 2002 Aug 27;2002(147):pl13.

PMID:
12198178
8.

Microarray analysis identifies differentially expressed genes induced by human papillomavirus type 18 E6 silencing RNA.

Min W, Wen-li M, Zhao-hui S, Ling L, Bao Z, Wen-ling Z.

Int J Gynecol Cancer. 2009 May;19(4):547-63. doi: 10.1111/IGC.0b013e3181a44c68.

PMID:
19509549
9.

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing.

Jackson AL, Burchard J, Leake D, Reynolds A, Schelter J, Guo J, Johnson JM, Lim L, Karpilow J, Nichols K, Marshall W, Khvorova A, Linsley PS.

RNA. 2006 Jul;12(7):1197-205. Epub 2006 May 8.

10.

Positional effects and strand preference of RNA interference against hepatitis C virus target sequences.

Smith RM, Smolic R, Volarevic M, Wu GY.

J Viral Hepat. 2007 Mar;14(3):194-212.

PMID:
17305886
11.

Accelerated off-target search algorithm for siRNA.

Yamada T, Morishita S.

Bioinformatics. 2005 Apr 15;21(8):1316-24. Epub 2004 Nov 25.

PMID:
15564304
13.

siRNA cell arrays for high-content screening microscopy.

Erfle H, Simpson JC, Bastiaens PI, Pepperkok R.

Biotechniques. 2004 Sep;37(3):454-8, 460, 462.

PMID:
15470900
14.

Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7.

Ravon M, Berrera M, Ebeling M, Certa U.

RNA Biol. 2012 Jan;9(1):87-97. doi: 10.4161/rna.9.1.18121. Epub 2012 Jan 1.

15.

Gene expression silencing with 'specific' small interfering RNA goes beyond specificity - a study of key parameters to take into account in the onset of small interfering RNA off-target effects.

Vankoningsloo S, de Longueville F, Evrard S, Rahier P, Houbion A, Fattaccioli A, Gastellier M, Remacle J, Raes M, Renard P, Arnould T.

FEBS J. 2008 Jun;275(11):2738-53. doi: 10.1111/j.1742-4658.2008.06415.x. Epub 2008 Apr 16.

16.

Novel insights into RNAi off-target effects using C. elegans paralogs.

Rual JF, Klitgord N, Achaz G.

BMC Genomics. 2007 Apr 19;8:106.

17.

Off-target effects of siRNA specific for GFP.

Tschuch C, Schulz A, Pscherer A, Werft W, Benner A, Hotz-Wagenblatt A, Barrionuevo LS, Lichter P, Mertens D.

BMC Mol Biol. 2008 Jun 24;9:60. doi: 10.1186/1471-2199-9-60.

18.

Identifying siRNA-induced off-targets by microarray analysis.

Anderson E, Boese Q, Khvorova A, Karpilow J.

Methods Mol Biol. 2008;442:45-63. doi: 10.1007/978-1-59745-191-8_4.

PMID:
18369777
19.

Effects of small interfering RNAs targeting MAPK1 on gene expression profile in HeLa cells as revealed by microarray analysis.

Huang C, Liu LY, Li ZF, Wang P, Ni L, Song LP, Xu DH, Song TS.

Cell Biol Int. 2008 Sep;32(9):1081-90. doi: 10.1016/j.cellbi.2008.04.019. Epub 2008 May 2.

PMID:
18539490
20.

Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing.

Chakraborty C.

Curr Drug Targets. 2007 Mar;8(3):469-82. Review.

PMID:
17348839

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