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Items: 1 to 20 of 74

1.

Solution structure of p53 core domain: structural basis for its instability.

Cañadillas JM, Tidow H, Freund SM, Rutherford TJ, Ang HC, Fersht AR.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2109-14. Epub 2006 Feb 6.

2.

Stability of the core domain of p53: insights from computer simulations.

Madhumalar A, Smith DJ, Verma C.

BMC Bioinformatics. 2008;9 Suppl 1:S17. doi: 10.1186/1471-2105-9-S1-S17.

3.

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core.

Khoo KH, Joerger AC, Freund SM, Fersht AR.

Protein Eng Des Sel. 2009 Jul;22(7):421-30. doi: 10.1093/protein/gzp018. Epub 2009 Jun 10.

4.

Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.

Wallentine BD, Wang Y, Tretyachenko-Ladokhina V, Tan M, Senear DF, Luecke H.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2146-56. doi: 10.1107/S0907444913020830. Epub 2013 Sep 20.

5.
6.

Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations.

Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z.

J Mol Biol. 2009 Jan 9;385(1):249-65. doi: 10.1016/j.jmb.2008.10.063. Epub 2008 Oct 30.

PMID:
18996393
7.

Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach.

Mora P, Carbajo RJ, Pineda-Lucena A, Sánchez del Pino MM, Pérez-Payá E.

Proteins. 2008 Jun;71(4):1670-85.

PMID:
18076077
8.

Core domain interactions in full-length p53 in solution.

Veprintsev DB, Freund SM, Andreeva A, Rutledge SE, Tidow H, Cañadillas JM, Blair CM, Fersht AR.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2115-9. Epub 2006 Feb 6.

9.

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

Wong KB, DeDecker BS, Freund SM, Proctor MR, Bycroft M, Fersht AR.

Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8438-42.

10.

Transient stability of the helical pattern of region F19-L22 of the N-terminal domain of p53: a molecular dynamics simulation study.

Espinoza-Fonseca LM, Trujillo-Ferrara JG.

Biochem Biophys Res Commun. 2006 Apr 28;343(1):110-6. Epub 2006 Mar 3.

PMID:
16530164
11.

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant.

Ishimaru D, Maia LF, Maiolino LM, Quesado PA, Lopez PC, Almeida FC, Valente AP, Silva JL.

J Mol Biol. 2003 Oct 17;333(2):443-51.

PMID:
14529628
12.

Kinetic instability of p53 core domain mutants: implications for rescue by small molecules.

Friedler A, Veprintsev DB, Hansson LO, Fersht AR.

J Biol Chem. 2003 Jun 27;278(26):24108-12. Epub 2003 Apr 16.

13.

High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds.

Ho WC, Luo C, Zhao K, Chai X, Fitzgerald MX, Marmorstein R.

Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1484-93. Epub 2006 Nov 23.

PMID:
17139084
14.

Probing phenylalanine environments in oligomeric structures with pentafluorophenylalanine and cyclohexylalanine.

Nomura T, Kamada R, Ito I, Sakamoto K, Chuman Y, Ishimori K, Shimohigashi Y, Sakaguchi K.

Biopolymers. 2011 Jun;95(6):410-9. doi: 10.1002/bip.21594.

PMID:
21280026
15.

Thermodynamic stability of wild-type and mutant p53 core domain.

Bullock AN, Henckel J, DeDecker BS, Johnson CM, Nikolova PV, Proctor MR, Lane DP, Fersht AR.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14338-42.

16.

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

Klein C, Georges G, Künkele KP, Huber R, Engh RA, Hansen S.

J Biol Chem. 2001 Oct 5;276(40):37390-401. Epub 2001 Jul 26.

17.

Water's potential role: Insights from studies of the p53 core domain.

Xu X, Ma Z, Wang X, Xiao ZT, Li Y, Xue ZH, Wang YH.

J Struct Biol. 2012 Feb;177(2):358-66. doi: 10.1016/j.jsb.2011.12.008. Epub 2011 Dec 14.

PMID:
22197648
18.

Aromatic ring-flipping in supercooled water: implications for NMR-based structural biology of proteins.

Skalicky JJ, Mills JL, Sharma S, Szyperski T.

J Am Chem Soc. 2001 Jan 24;123(3):388-97.

PMID:
11456540
19.

Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.

Eldar A, Rozenberg H, Diskin-Posner Y, Rohs R, Shakked Z.

Nucleic Acids Res. 2013 Oct;41(18):8748-59. doi: 10.1093/nar/gkt630. Epub 2013 Jul 17.

20.

NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA.

Klein C, Planker E, Diercks T, Kessler H, Künkele KP, Lang K, Hansen S, Schwaiger M.

J Biol Chem. 2001 Dec 28;276(52):49020-7. Epub 2001 Oct 17.

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