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Items: 1 to 20 of 202


Structural and dynamic characterization of a vinculin binding site in the talin rod.

Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL.

Biochemistry. 2006 Feb 14;45(6):1805-17.


A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL.

Structure. 2005 Jan;13(1):65-74.


Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

Gingras AR, Ziegler WH, Frank R, Barsukov IL, Roberts GC, Critchley DR, Emsley J.

J Biol Chem. 2005 Nov 4;280(44):37217-24. Epub 2005 Aug 30.


The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

Patel B, Gingras AR, Bobkov AA, Fujimoto LM, Zhang M, Liddington RC, Mazzeo D, Emsley J, Roberts GC, Barsukov IL, Critchley DR.

J Biol Chem. 2006 Mar 17;281(11):7458-67. Epub 2006 Jan 9.


Integrin connections to the cytoskeleton through talin and vinculin.

Ziegler WH, Gingras AR, Critchley DR, Emsley J.

Biochem Soc Trans. 2008 Apr;36(Pt 2):235-9. doi: 10.1042/BST0360235. Review.


Structural basis for amplifying vinculin activation by talin.

Izard T, Vonrhein C.

J Biol Chem. 2004 Jun 25;279(26):27667-78. Epub 2004 Apr 7.


Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.

Bass MD, Smith BJ, Prigent SA, Critchley DR.

Biochem J. 1999 Jul 15;341 ( Pt 2):257-63.


Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.

Cohen DM, Chen H, Johnson RP, Choudhury B, Craig SW.

J Biol Chem. 2005 Apr 29;280(17):17109-17. Epub 2005 Feb 22.


Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, Frank R, Ziegler WH, Roberts GC, Critchley DR, Emsley J.

EMBO J. 2004 Aug 4;23(15):2942-51. Epub 2004 Jul 22.


Further characterisation of the talin-binding site in the cytoskeletal protein vinculin.

Gilmore AP, Jackson P, Waites GT, Critchley DR.

J Cell Sci. 1992 Nov;103 ( Pt 3):719-31.


A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain.

Tremuth L, Kreis S, Melchior C, Hoebeke J, Rondé P, Plançon S, Takeda K, Kieffer N.

J Biol Chem. 2004 May 21;279(21):22258-66. Epub 2004 Mar 18.


Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.

Yogesha SD, Rangarajan ES, Vonrhein C, Bricogne G, Izard T.

Protein Sci. 2012 Apr;21(4):583-8. doi: 10.1002/pro.2041. Epub 2012 Feb 28.


The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.

Moes M, Rodius S, Coleman SJ, Monkley SJ, Goormaghtigh E, Tremuth L, Kox C, van der Holst PP, Critchley DR, Kieffer N.

J Biol Chem. 2007 Jun 8;282(23):17280-8. Epub 2007 Apr 11.


Vinculin activation by talin through helical bundle conversion.

Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR.

Nature. 2004 Jan 8;427(6970):171-5. Epub 2003 Dec 31.


The domain structure of talin: residues 1815-1973 form a five-helix bundle containing a cryptic vinculin-binding site.

Goult BT, Gingras AR, Bate N, Barsukov IL, Critchley DR, Roberts GC.

FEBS Lett. 2010 Jun 3;584(11):2237-41. doi: 10.1016/j.febslet.2010.04.028. Epub 2010 Apr 20.


Identification of a talin binding site in the cytoskeletal protein vinculin.

Jones P, Jackson P, Price GJ, Patel B, Ohanion V, Lear AL, Critchley DR.

J Cell Biol. 1989 Dec;109(6 Pt 1):2917-27.


The cytoskeletal protein talin contains at least two distinct vinculin binding domains.

Gilmore AP, Wood C, Ohanian V, Jackson P, Patel B, Rees DJ, Hynes RO, Critchley DR.

J Cell Biol. 1993 Jul;122(2):337-47.


Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site.

Hemmings L, Rees DJ, Ohanian V, Bolton SJ, Gilmore AP, Patel B, Priddle H, Trevithick JE, Hynes RO, Critchley DR.

J Cell Sci. 1996 Nov;109 ( Pt 11):2715-26.


Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin.

Rush CL, Izard T.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):945-7. Epub 2004 Apr 21.


Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin.

Yogesha SD, Sharff A, Bricogne G, Izard T.

Protein Sci. 2011 Aug;20(8):1471-6. doi: 10.1002/pro.671.

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