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Items: 1 to 20 of 198

1.

Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.

Mahindroo N, Wang CC, Liao CC, Huang CF, Lu IL, Lien TW, Peng YH, Huang WJ, Lin YT, Hsu MC, Lin CH, Tsai CH, Hsu JT, Chen X, Lyu PC, Chao YS, Wu SY, Hsieh HP.

J Med Chem. 2006 Feb 9;49(3):1212-6.

PMID:
16451087
2.

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists.

Peng YH, Coumar MS, Leou JS, Wu JS, Shiao HY, Lin CH, Lin WH, Lien TW, Chen X, Hsu JT, Chao YS, Huang CF, Lyu PC, Hsieh HP, Wu SY.

ChemMedChem. 2010 Oct 4;5(10):1707-16. doi: 10.1002/cmdc.201000194.

PMID:
20734309
3.

Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities.

Lu IL, Huang CF, Peng YH, Lin YT, Hsieh HP, Chen CT, Lien TW, Lee HJ, Mahindroo N, Prakash E, Yueh A, Chen HY, Goparaju CM, Chen X, Liao CC, Chao YS, Hsu JT, Wu SY.

J Med Chem. 2006 May 4;49(9):2703-12.

PMID:
16640330
4.

Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids.

Waku T, Shiraki T, Oyama T, Fujimoto Y, Maebara K, Kamiya N, Jingami H, Morikawa K.

J Mol Biol. 2009 Jan 9;385(1):188-99. doi: 10.1016/j.jmb.2008.10.039. Epub 2008 Oct 19.

PMID:
18977231
5.

Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.

Mahindroo N, Peng YH, Lin CH, Tan UK, Prakash E, Lien TW, Lu IL, Lee HJ, Hsu JT, Chen X, Liao CC, Lyu PC, Chao YS, Wu SY, Hsieh HP.

J Med Chem. 2006 Oct 19;49(21):6421-4.

PMID:
17034149
6.

Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists.

Ahn JH, Shin MS, Jung SH, Kang SK, Kim KR, Rhee SD, Jung WH, Yang SD, Kim SJ, Woo JR, Lee JH, Cheon HG, Kim SS.

J Med Chem. 2006 Jul 27;49(15):4781-4.

PMID:
16854085
7.

Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities.

Mahindroo N, Huang CF, Peng YH, Wang CC, Liao CC, Lien TW, Chittimalla SK, Huang WJ, Chai CH, Prakash E, Chen CP, Hsu TA, Peng CH, Lu IL, Lee LH, Chang YW, Chen WC, Chou YC, Chen CT, Goparaju CM, Chen YS, Lan SJ, Yu MC, Chen X, Chao YS, Wu SY, Hsieh HP.

J Med Chem. 2005 Dec 29;48(26):8194-208.

PMID:
16366601
8.

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists.

Lin CH, Peng YH, Coumar MS, Chittimalla SK, Liao CC, Lyn PC, Huang CC, Lien TW, Lin WH, Hsu JT, Cheng JH, Chen X, Wu JS, Chao YS, Lee HJ, Juo CG, Wu SY, Hsieh HP.

J Med Chem. 2009 Apr 23;52(8):2618-22. doi: 10.1021/jm801594x.

PMID:
19301897
10.

Design, synthesis, and structural analysis of phenylpropanoic acid-type PPAR╬│-selective agonists: discovery of reversed stereochemistry-activity relationship.

Ohashi M, Oyama T, Nakagome I, Satoh M, Nishio Y, Nobusada H, Hirono S, Morikawa K, Hashimoto Y, Miyachi H.

J Med Chem. 2011 Jan 13;54(1):331-41. doi: 10.1021/jm101233f. Epub 2010 Dec 3.

PMID:
21128600
11.

Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).

Dong X, Zhang Z, Wen R, Shen J, Shen X, Jiang H.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5913-6. Epub 2006 Sep 28.

PMID:
17010604
12.

Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

Suzuki T, Igari S, Hirasawa A, Hata M, Ishiguro M, Fujieda H, Itoh Y, Hirano T, Nakagawa H, Ogura M, Makishima M, Tsujimoto G, Miyata N.

J Med Chem. 2008 Dec 11;51(23):7640-4. doi: 10.1021/jm800970b.

PMID:
19007110
13.

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma.

Gani OA, Sylte I.

Chem Biol Drug Des. 2008 Jul;72(1):50-7. doi: 10.1111/j.1747-0285.2008.00677.x. Epub 2008 Jun 11.

PMID:
18554251
14.

Novel PPAR-gamma agonists identified from a natural product library: a virtual screening, induced-fit docking and biological assay study.

Salam NK, Huang TH, Kota BP, Kim MS, Li Y, Hibbs DE.

Chem Biol Drug Des. 2008 Jan;71(1):57-70. Epub 2007 Dec 18.

PMID:
18086153
15.

[Design and synthesis of peroxisome proliferator-activated receptor (PPAR) delta agonists and its implication to the driving force to elicit PPAR delta selectivity].

Kasuga J, Oyama T, Nakagome I, Aoyama A, Sako K, Makishima M, Hirono S, Morikawa K, Hashimoto Y, Miyachi H.

Yakugaku Zasshi. 2009 Jun;129(6):709-18. Review. Japanese.

16.

Structure-activity relationships and key structural feature of pyridyloxybenzene-acylsulfonamides as new, potent, and selective peroxisome proliferator-activated receptor (PPAR) ╬│ Agonists.

Rikimaru K, Wakabayashi T, Abe H, Tawaraishi T, Imoto H, Yonemori J, Hirose H, Murase K, Matsuo T, Matsumoto M, Nomura C, Tsuge H, Arimura N, Kawakami K, Sakamoto J, Funami M, Mol CD, Snell GP, Bragstad KA, Sang BC, Dougan DR, Tanaka T, Katayama N, Horiguchi Y, Momose Y.

Bioorg Med Chem. 2012 May 15;20(10):3332-58. doi: 10.1016/j.bmc.2012.03.036. Epub 2012 Mar 23.

PMID:
22503460
17.

New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.

Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G, Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F.

J Med Chem. 2009 Oct 22;52(20):6382-93. doi: 10.1021/jm900941b.

PMID:
19775169
18.

Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARgamma activators.

Kumar R, Mittal A, Ramachandran U.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4613-8. Epub 2007 May 31.

PMID:
17574414
20.

Indanylacetic acid derivatives carrying 4-thiazolyl-phenoxy tail groups, a new class of potent PPAR alpha/gamma/delta pan agonists: synthesis, structure-activity relationship, and in vivo efficacy.

Rudolph J, Chen L, Majumdar D, Bullock WH, Burns M, Claus T, Dela Cruz FE, Daly M, Ehrgott FJ, Johnson JS, Livingston JN, Schoenleber RW, Shapiro J, Yang L, Tsutsumi M, Ma X.

J Med Chem. 2007 Mar 8;50(5):984-1000. Epub 2007 Feb 3.

PMID:
17274610

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