Similar articles for PMID: 16443686

Year	Number of Results
2004	7
2005	11
2006	22
2007	20
2008	20
2009	28
2010	28
2011	36
2012	44
2013	37
2014	32
2015	50
2016	41
2017	16
2018	32
2019	18
2020	11
2021	16
2022	12
2023	8
2024	0

1

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.

Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT. Tovar C, et al. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93. doi: 10.1073/pnas.0507493103. Epub 2006 Jan 27. Proc Natl Acad Sci U S A. 2006. PMID: 16443686 Free PMC article.

2

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

Van Maerken T, Ferdinande L, Taildeman J, Lambertz I, Yigit N, Vercruysse L, Rihani A, Michaelis M, Cinatl J Jr, Cuvelier CA, Marine JC, De Paepe A, Bracke M, Speleman F, Vandesompele J. Van Maerken T, et al. J Natl Cancer Inst. 2009 Nov 18;101(22):1562-74. doi: 10.1093/jnci/djp355. Epub 2009 Nov 10. J Natl Cancer Inst. 2009. PMID: 19903807

3

Restoration of p53 pathway by nutlin-3 induces cell cycle arrest and apoptosis in human rhabdomyosarcoma cells.

Miyachi M, Kakazu N, Yagyu S, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tsuchiya K, Iehara T, Hosoi H. Miyachi M, et al. Clin Cancer Res. 2009 Jun 15;15(12):4077-84. doi: 10.1158/1078-0432.CCR-08-2955. Epub 2009 Jun 9. Clin Cancer Res. 2009. PMID: 19509161

4

MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models.

Tovar C, Graves B, Packman K, Filipovic Z, Higgins B, Xia M, Tardell C, Garrido R, Lee E, Kolinsky K, To KH, Linn M, Podlaski F, Wovkulich P, Vu B, Vassilev LT. Tovar C, et al. Cancer Res. 2013 Apr 15;73(8):2587-97. doi: 10.1158/0008-5472.CAN-12-2807. Epub 2013 Feb 11. Cancer Res. 2013. PMID: 23400593

5

Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.

Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I. Endo S, et al. Cancer Sci. 2011 Mar;102(3):605-13. doi: 10.1111/j.1349-7006.2010.01821.x. Epub 2011 Jan 12. Cancer Sci. 2011. PMID: 21205074 Free article.

6

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas.

Künkele A, De Preter K, Heukamp L, Thor T, Pajtler KW, Hartmann W, Mittelbronn M, Grotzer MA, Deubzer HE, Speleman F, Schramm A, Eggert A, Schulte JH. Künkele A, et al. Neuro Oncol. 2012 Jul;14(7):859-69. doi: 10.1093/neuonc/nos115. Epub 2012 May 16. Neuro Oncol. 2012. PMID: 22591662 Free PMC article.

7

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines.

Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. Kitagawa M, et al. Oncogene. 2008 Sep 11;27(40):5303-14. doi: 10.1038/onc.2008.164. Epub 2008 Jun 2. Oncogene. 2008. PMID: 18521084

8

Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.

Zhang L, Zhang J, Hu C, Cao J, Zhou X, Hu Y, He Q, Yang B. Zhang L, et al. Anticancer Drugs. 2009 Jul;20(6):416-24. doi: 10.1097/cad.0b013e32832aa7b0. Anticancer Drugs. 2009. PMID: 19579266

9

Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation.

Mochizuki H, Goto-Koshino Y, Sato M, Fujino Y, Ohno K, Tsujimoto H. Mochizuki H, et al. Vet Immunol Immunopathol. 2012 Jun 30;147(3-4):187-94. doi: 10.1016/j.vetimm.2012.04.017. Epub 2012 Apr 20. Vet Immunol Immunopathol. 2012. PMID: 22578852

10

Inhibiting MDM2-p53 Interaction Suppresses Tumor Growth in Patient-Derived Non-Small Cell Lung Cancer Xenograft Models.

Hai J, Sakashita S, Allo G, Ludkovski O, Ng C, Shepherd FA, Tsao MS. Hai J, et al. J Thorac Oncol. 2015 Aug;10(8):1172-80. doi: 10.1097/JTO.0000000000000584. J Thorac Oncol. 2015. PMID: 26200271 Free article.

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