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Items: 1 to 20 of 99

1.

A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.

Schmidt RJ, Ficorilli JV, Zhang Y, Bramlett KS, Beyer TP, Borchert K, Dowless MS, Houck KA, Burris TP, Eacho PI, Liang G, Guo LW, Wilson WK, Michael LF, Cao G.

J Lipid Res. 2006 May;47(5):1037-44. Epub 2006 Jan 13.

2.

Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.

Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J.

J Biol Chem. 2008 Jan 25;283(4):2129-38. Epub 2007 Nov 20.

3.

27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.

Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG.

J Biol Chem. 2001 Oct 19;276(42):38378-87. Epub 2001 Aug 14.

4.

Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH.

J Biol Chem. 2006 Sep 22;281(38):27816-26. Epub 2006 Jul 20.

5.

Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.

Trasino SE, Kim YS, Wang TT.

Mol Cancer Ther. 2009 Jul;8(7):1934-45. doi: 10.1158/1535-7163.MCT-09-0020. Epub 2009 Jun 16.

6.

Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9. Epub 2006 Jul 6.

7.

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1454-9. Epub 2004 Jun 3.

8.

Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.

Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T.

J Biol Chem. 2007 Jul 20;282(29):21090-9. Epub 2007 May 27.

10.

Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP.

Biochem Pharmacol. 2006 Feb 14;71(4):453-63. Epub 2005 Dec 2.

PMID:
16325781
11.

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.

Wang J, Einarsson C, Murphy C, Parini P, Björkhem I, Gåfvels M, Eggertsen G.

J Lipid Res. 2006 Feb;47(2):421-30. Epub 2005 Nov 1.

12.
13.

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.

Costet P, Cariou B, Lambert G, Lalanne F, Lardeux B, Jarnoux AL, Grefhorst A, Staels B, Krempf M.

J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.

14.

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

Abildayeva K, Jansen PJ, Hirsch-Reinshagen V, Bloks VW, Bakker AH, Ramaekers FC, de Vente J, Groen AK, Wellington CL, Kuipers F, Mulder M.

J Biol Chem. 2006 May 5;281(18):12799-808. Epub 2006 Mar 8.

15.

Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol.

Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, Xu G, Lea M, Salen G.

Hepatology. 2006 Sep;44(3):602-11.

PMID:
16941710
16.

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N.

Mol Endocrinol. 2003 Jul;17(7):1255-67. Epub 2003 May 1.

PMID:
12730332
17.

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells.

DiBlasio-Smith EA, Arai M, Quinet EM, Evans MJ, Kornaga T, Basso MD, Chen L, Feingold I, Halpern AR, Liu QY, Nambi P, Savio D, Wang S, Mounts WM, Isler JA, Slager AM, Burczynski ME, Dorner AJ, LaVallie ER.

J Transl Med. 2008 Oct 16;6:59. doi: 10.1186/1479-5876-6-59.

18.

A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.

de Vogel-van den Bosch HM, de Wit NJ, Hooiveld GJ, Vermeulen H, van der Veen JN, Houten SM, Kuipers F, Müller M, van der Meer R.

Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1171-80. doi: 10.1152/ajpgi.00360.2007. Epub 2008 Mar 20.

19.

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity.

Endo-Umeda K, Yasuda K, Sugita K, Honda A, Ohta M, Ishikawa M, Hashimoto Y, Sakaki T, Makishima M.

J Steroid Biochem Mol Biol. 2014 Mar;140:7-16. doi: 10.1016/j.jsbmb.2013.11.010. Epub 2013 Nov 21.

PMID:
24269243
20.

Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue.

Ulven SM, Dalen KT, Gustafsson JA, Nebb HI.

J Lipid Res. 2004 Nov;45(11):2052-62. Epub 2004 Aug 1.

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