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Items: 1 to 20 of 138


Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.

Schmidt MH, Husnjak K, Szymkiewicz I, Haglund K, Dikic I.

Oncogene. 2006 May 18;25(21):3071-8.


Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.

Hoelz A, Janz JM, Lawrie SD, Corwin B, Lee A, Sakmar TP.

J Mol Biol. 2006 Apr 28;358(2):509-22. Epub 2006 Feb 28.


The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.

Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA.

FEBS Lett. 2003 Aug 28;550(1-3):119-23.


Cbl promotes clustering of endocytic adaptor proteins.

Jozic D, Cárdenes N, Deribe YL, Moncalián G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J.

Nat Struct Mol Biol. 2005 Nov;12(11):972-9.


betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth.

Shin EY, Lee CS, Cho TG, Kim YG, Song S, Juhnn YS, Park SC, Manser E, Kim EG.

J Biol Chem. 2006 Nov 24;281(47):35954-64. Epub 2006 Sep 5.


BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling.

Lee SH, Eom M, Lee SJ, Kim S, Park HJ, Park D.

J Biol Chem. 2001 Jul 6;276(27):25066-72. Epub 2001 Apr 17.


Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.

Feng Q, Baird D, Peng X, Wang J, Ly T, Guan JL, Cerione RA.

Nat Cell Biol. 2006 Sep;8(9):945-56. Epub 2006 Aug 6.


Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases.

Feng Q, Albeck JG, Cerione RA, Yang W.

J Biol Chem. 2002 Feb 15;277(7):5644-50. Epub 2001 Dec 10.


Src transforms in a Cool way.

Peterson JR, Chernoff J.

Nat Cell Biol. 2006 Sep;8(9):905-7. No abstract available.


The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.

Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, Kim E.

J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.


Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation.

Wu WJ, Tu S, Cerione RA.

Cell. 2003 Sep 19;114(6):715-25.


Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

Kowanetz K, Szymkiewicz I, Haglund K, Kowanetz M, Husnjak K, Taylor JD, Soubeyran P, Engstrom U, Ladbury JE, Dikic I.

J Biol Chem. 2003 Oct 10;278(41):39735-46. Epub 2003 Jul 21.


Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).

Mott HR, Nietlispach D, Evetts KA, Owen D.

Biochemistry. 2005 Aug 23;44(33):10977-83.


Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix.

Feng Q, Baird D, Cerione RA.

EMBO J. 2004 Sep 1;23(17):3492-504. Epub 2004 Aug 12.


Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.

Duan L, Raja SM, Chen G, Virmani S, Williams SH, Clubb RJ, Mukhopadhyay C, Rainey MA, Ying G, Dimri M, Chen J, Reddi AL, Naramura M, Band V, Band H.

J Biol Chem. 2011 Jan 7;286(1):620-33. doi: 10.1074/jbc.M110.188086. Epub 2010 Oct 12.


Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.

Parrini MC, Lei M, Harrison SC, Mayer BJ.

Mol Cell. 2002 Jan;9(1):73-83.


Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix.

ten Klooster JP, Jaffer ZM, Chernoff J, Hordijk PL.

J Cell Biol. 2006 Feb 27;172(5):759-69. Epub 2006 Feb 21.


A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

Ku GM, Yablonski D, Manser E, Lim L, Weiss A.

EMBO J. 2001 Feb 1;20(3):457-65.

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