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Items: 1 to 20 of 112

1.

PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.

Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.

J Biol Chem. 2006 Mar 10;281(10):6246-52. Epub 2006 Jan 9.

2.

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.

Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T.

EMBO J. 2006 Mar 8;25(5):1126-36. Epub 2006 Feb 16.

4.

Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage.

Roukos V, Kinkhabwala A, Colombelli J, Kotsantis P, Taraviras S, Nishitani H, Stelzer E, Bastiaens P, Lygerou Z.

J Cell Sci. 2011 Feb 1;124(Pt 3):422-34. doi: 10.1242/jcs.074229. Epub 2011 Jan 11.

5.

L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.

Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H.

Cell Cycle. 2006 Aug;5(15):1675-80. Epub 2006 Aug 1.

PMID:
16861906
6.

Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.

Hu J, McCall CM, Ohta T, Xiong Y.

Nat Cell Biol. 2004 Oct;6(10):1003-9. Epub 2004 Sep 26.

PMID:
15448697
7.

PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication.

Arias EE, Walter JC.

Nat Cell Biol. 2006 Jan;8(1):84-90. Epub 2005 Dec 18.

PMID:
16362051
8.

The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation.

Li X, Zhao Q, Liao R, Sun P, Wu X.

J Biol Chem. 2003 Aug 15;278(33):30854-8. Epub 2003 Jul 2.

9.
10.

PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.

Genes Dev. 2008 Sep 15;22(18):2496-506. doi: 10.1101/gad.1676108.

11.

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T.

J Biol Chem. 2008 Oct 24;283(43):29045-52. doi: 10.1074/jbc.M806045200. Epub 2008 Aug 14.

12.

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV irradiation.

Shiomi Y, Hayashi A, Ishii T, Shinmyozu K, Nakayama J, Sugasawa K, Nishitani H.

Mol Cell Biol. 2012 Jun;32(12):2279-88. doi: 10.1128/MCB.06506-11. Epub 2012 Apr 9.

13.

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1.

Ralph E, Boye E, Kearsey SE.

EMBO Rep. 2006 Nov;7(11):1134-9. Epub 2006 Oct 13. Erratum in: EMBO Rep. 2007 Feb;8(2):200.

14.

Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.

Lee HO, Zacharek SJ, Xiong Y, Duronio RJ.

Mol Biol Cell. 2010 Nov 1;21(21):3639-53. doi: 10.1091/mbc.E10-02-0130. Epub 2010 Sep 8.

15.

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.

Liu E, Li X, Yan F, Zhao Q, Wu X.

J Biol Chem. 2004 Apr 23;279(17):17283-8. Epub 2004 Mar 5.

16.

Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.

Ishii T, Shiomi Y, Takami T, Murakami Y, Ohnishi N, Nishitani H.

J Biol Chem. 2010 Dec 31;285(53):41993-2000. doi: 10.1074/jbc.M110.161661. Epub 2010 Oct 7.

17.

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

Hall JR, Lee HO, Bunker BD, Dorn ES, Rogers GC, Duronio RJ, Cook JG.

J Biol Chem. 2008 Sep 12;283(37):25356-63. doi: 10.1074/jbc.M802667200. Epub 2008 Jul 10.

18.
19.

Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

Guarino E, Shepherd ME, Salguero I, Hua H, Deegan RS, Kearsey SE.

Nucleic Acids Res. 2011 Aug;39(14):5978-90. doi: 10.1093/nar/gkr222. Epub 2011 Apr 14.

20.

CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.

Rizzardi LF, Coleman KE, Varma D, Matson JP, Oh S, Cook JG.

J Biol Chem. 2015 Jan 2;290(1):556-67. doi: 10.1074/jbc.M114.614701. Epub 2014 Nov 19.

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