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Items: 1 to 20 of 203

1.

Individual metal ligands play distinct functional roles in the zinc sensor Staphylococcus aureus CzrA.

Pennella MA, Arunkumar AI, Giedroc DP.

J Mol Biol. 2006 Mar 10;356(5):1124-36. Epub 2005 Dec 22.

PMID:
16406068
2.

Structural insights into homo- and heterotropic allosteric coupling in the zinc sensor S. aureus CzrA from covalently fused dimers.

Lee S, Arunkumar AI, Chen X, Giedroc DP.

J Am Chem Soc. 2006 Feb 15;128(6):1937-47.

PMID:
16464095
3.

A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.

Eicken C, Pennella MA, Chen X, Koshlap KM, VanZile ML, Sacchettini JC, Giedroc DP.

J Mol Biol. 2003 Oct 31;333(4):683-95.

PMID:
14568530
6.

Studying allosteric regulation in metal sensor proteins using computational methods.

Chakravorty DK, Merz KM Jr.

Adv Protein Chem Struct Biol. 2014;96:181-218. doi: 10.1016/bs.apcsb.2014.06.009. Epub 2014 Sep 6. Review.

PMID:
25443958
7.

Simulations of allosteric motions in the zinc sensor CzrA.

Chakravorty DK, Wang B, Lee CW, Giedroc DP, Merz KM Jr.

J Am Chem Soc. 2012 Feb 22;134(7):3367-76. doi: 10.1021/ja208047b. Epub 2011 Nov 14.

8.

Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family.

Campanello GC, Ma Z, Grossoehme NE, Guerra AJ, Ward BP, Dimarchi RD, Ye Y, Dann CE 3rd, Giedroc DP.

J Mol Biol. 2013 Apr 12;425(7):1143-57. doi: 10.1016/j.jmb.2013.01.018. Epub 2013 Jan 23.

9.

Solution structure of a paradigm ArsR family zinc sensor in the DNA-bound state.

Arunkumar AI, Campanello GC, Giedroc DP.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18177-82. doi: 10.1073/pnas.0905558106. Epub 2009 Oct 12.

10.

Structural determinants of metal selectivity in prokaryotic metal-responsive transcriptional regulators.

Pennella MA, Giedroc DP.

Biometals. 2005 Aug;18(4):413-28. Review.

PMID:
16158234
11.

Role of the N-terminal helix in the metal ion-induced activation of the diphtheria toxin repressor DtxR.

D'Aquino JA, Lattimer JR, Denninger A, D'Aquino KE, Ringe D.

Biochemistry. 2007 Oct 23;46(42):11761-70. Epub 2007 Sep 29.

PMID:
17902703
12.

Kinetics of metal binding by the toxic metal-sensing transcriptional repressor Staphylococcus aureus pI258 CadC.

Busenlehner LS, Giedroc DP.

J Inorg Biochem. 2006 May;100(5-6):1024-34. Epub 2006 Feb 17.

PMID:
16487591
13.

Characterization of a metalloregulatory bismuth(III) site in Staphylococcus aureus pI258 CadC repressor.

Busenlehner LS, Apuy JL, Giedroc DP.

J Biol Inorg Chem. 2002 Apr;7(4-5):551-9. Epub 2002 Feb 8.

PMID:
11941514
14.

19F-NMR reveals metal and operator-induced allostery in MerR.

Song L, Teng Q, Phillips RS, Brewer JM, Summers AO.

J Mol Biol. 2007 Aug 3;371(1):79-92. Epub 2007 May 10.

PMID:
17560604
15.
16.

A nickel-cobalt-sensing ArsR-SmtB family repressor. Contributions of cytosol and effector binding sites to metal selectivity.

Cavet JS, Meng W, Pennella MA, Appelhoff RJ, Giedroc DP, Robinson NJ.

J Biol Chem. 2002 Oct 11;277(41):38441-8. Epub 2002 Aug 5.

17.

Decreased sensitivity to changes in the concentration of metal ions as the basis for the hyperactivity of DtxR(E175K).

D'Aquino JA, Denninger AR, Moulin AG, D'Aquino KE, Ringe D.

J Mol Biol. 2009 Jul 3;390(1):112-23. doi: 10.1016/j.jmb.2009.05.003. Epub 2009 May 8.

PMID:
19433095
18.
19.

Energetics of allosteric negative coupling in the zinc sensor S. aureus CzrA.

Grossoehme NE, Giedroc DP.

J Am Chem Soc. 2009 Dec 16;131(49):17860-70. doi: 10.1021/ja906131b.

20.

Structural elements of metal selectivity in metal sensor proteins.

Pennella MA, Shokes JE, Cosper NJ, Scott RA, Giedroc DP.

Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3713-8. Epub 2003 Mar 21.

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