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Items: 1 to 20 of 61

1.

[Effect of an inhibitor of alpha-secretase metabolizing amyloid precursor protein on memory in rats].

Dubrovskaia NM, Nalivaeva NN, Turner AJ, Zhuravin IA.

Zh Vyssh Nerv Deiat Im I P Pavlova. 2005 Nov-Dec;55(6):725-8. Russian.

PMID:
16396478
2.

Effects of an inhibitor of alpha-secretase, which metabolizes the amyloid peptide precursor, on memory formation in rats.

Dubrovskaya NM, Nalivaeva NN, Turner AJ, Zhuravin IA.

Neurosci Behav Physiol. 2006 Nov;36(9):911-3.

PMID:
17024329
4.

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits.

Anderson JJ, Holtz G, Baskin PP, Wang R, Mazzarelli L, Wagner SL, Menzaghi F.

Neuroscience. 1999;93(4):1409-20.

PMID:
10501466
6.

The amyloid precursor protein (APP) and the angiotensin converting enzyme (ACE) secretase are inhibited by hydroxamic acid-based inhibitors.

Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM.

Biochem Soc Trans. 1998 Aug;26(3):S242. No abstract available.

PMID:
9765961
7.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

8.

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.

J Pharmacol Exp Ther. 2008 Mar;324(3):957-69. Epub 2007 Dec 21.

9.

Blockade of gamma-secretase activity within the hippocampus enhances long-term memory.

Dash PK, Moore AN, Orsi SA.

Biochem Biophys Res Commun. 2005 Dec 16;338(2):777-82. Epub 2005 Oct 11.

PMID:
16246305
10.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

11.

A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.

Alfalah M, Parkin ET, Jacob R, Sturrock ED, Mentele R, Turner AJ, Hooper NM, Naim HY.

J Biol Chem. 2001 Jun 15;276(24):21105-9. Epub 2001 Mar 23.

12.

Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory.

Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC.

Neurobiol Dis. 2008 Aug;31(2):250-60. doi: 10.1016/j.nbd.2008.04.011. Epub 2008 May 10.

PMID:
18585048
13.

BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.

Yoon SY, Choi JE, Yoon JH, Huh JW, Kim DH.

Neurobiol Dis. 2006 May;22(2):435-44. Epub 2006 Feb 9.

PMID:
16480887
14.

Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice.

Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT.

J Nutr. 2009 Oct;139(10):1987-93. doi: 10.3945/jn.109.109785. Epub 2009 Aug 5.

PMID:
19656855
15.

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.

Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.

J Neurochem. 2007 Feb;100(3):802-9.

16.
17.

Beta-amyloid pathology in the entorhinal cortex of rats induces memory deficits: implications for Alzheimer's disease.

Sipos E, Kurunczi A, Kasza A, Horváth J, Felszeghy K, Laroche S, Toldi J, Párducz A, Penke B, Penke Z.

Neuroscience. 2007 Jun 15;147(1):28-36. Epub 2007 May 17.

PMID:
17499931
18.

Retinoic acid normalizes nuclear receptor mediated hypo-expression of proteins involved in beta-amyloid deposits in the cerebral cortex of vitamin A deprived rats.

Husson M, Enderlin V, Delacourte A, Ghenimi N, Alfos S, Pallet V, Higueret P.

Neurobiol Dis. 2006 Jul;23(1):1-10. Epub 2006 Mar 10.

PMID:
16531051
19.

Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.

Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J.

ACS Chem Neurosci. 2016 Jan 20;7(1):40-5. doi: 10.1021/acschemneuro.5b00283. Epub 2015 Nov 18.

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