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AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer.

Moyano JV, Evans JR, Chen F, Lu M, Werner ME, Yehiely F, Diaz LK, Turbin D, Karaca G, Wiley E, Nielsen TO, Perou CM, Cryns VL.

J Clin Invest. 2006 Jan;116(1):261-70.


AlphaB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas.

Sitterding SM, Wiseman WR, Schiller CL, Luan C, Chen F, Moyano JV, Watkin WG, Wiley EL, Cryns VL, Diaz LK.

Ann Diagn Pathol. 2008 Feb;12(1):33-40. doi: 10.1016/j.anndiagpath.2007.02.004. Epub 2007 Oct 24.


Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast cancer.

Bosman JD, Yehiely F, Evans JR, Cryns VL.

Breast Cancer Res Treat. 2010 Jan;119(1):63-70. doi: 10.1007/s10549-009-0330-4. Epub 2009 Feb 11.


Is the small heat shock protein alphaB-crystallin an oncogene?

Gruvberger-Saal SK, Parsons R.

J Clin Invest. 2006 Jan;116(1):30-2.


αB-crystallin: a novel regulator of breast cancer metastasis to the brain.

Malin D, Strekalova E, Petrovic V, Deal AM, Al Ahmad A, Adamo B, Miller CR, Ugolkov A, Livasy C, Fritchie K, Hamilton E, Blackwell K, Geradts J, Ewend M, Carey L, Shusta EV, Anders CK, Cryns VL.

Clin Cancer Res. 2014 Jan 1;20(1):56-67. doi: 10.1158/1078-0432.CCR-13-1255. Epub 2013 Oct 16.


ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo.

Malin D, Strekalova E, Petrovic V, Rajanala H, Sharma B, Ugolkov A, Gradishar WJ, Cryns VL.

Oncogene. 2015 Nov 5;34(45):5626-34. doi: 10.1038/onc.2015.12. Epub 2015 Feb 16.


Serine 59 phosphorylation of {alpha}B-crystallin down-regulates its anti-apoptotic function by binding and sequestering Bcl-2 in breast cancer cells.

Launay N, Tarze A, Vicart P, Lilienbaum A.

J Biol Chem. 2010 Nov 26;285(48):37324-32. doi: 10.1074/jbc.M110.124388. Epub 2010 Sep 14.


αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation.

Petrovic V, Malin D, Cryns VL.

Breast Cancer Res Treat. 2013 Apr;138(2):415-25. doi: 10.1007/s10549-013-2465-6. Epub 2013 Mar 8.


αB-crystallin expression is correlated with phospho-ERK1/2 expression in human breast cancer.

van de Schootbrugge C, van Asten F, Nagtegaal ID, Versleijen-Jonkers YM, van Laarhoven HW, Roeffen MH, Sweep FC, Bussink J, Kaanders JH, Pruijn GJ, Boelens WC, Span PN.

Int J Biol Markers. 2013 Dec 17;28(4):e365-70. doi: 10.5301/jbm.5000032.


alphaB-crystallin is a marker of aggressive breast cancer behavior but does not independently predict for patient outcome: a combined analysis of two randomized studies.

Koletsa T, Stavridi F, Bobos M, Kostopoulos I, Kotoula V, Eleftheraki AG, Konstantopoulou I, Papadimitriou C, Batistatou A, Gogas H, Koutras A, Skarlos DV, Pentheroudakis G, Efstratiou I, Pectasides D, Fountzilas G.

BMC Clin Pathol. 2014 Jun 23;14:28. doi: 10.1186/1472-6890-14-28. eCollection 2014.


alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer.

Ivanov O, Chen F, Wiley EL, Keswani A, Diaz LK, Memmel HC, Rademaker A, Gradishar WJ, Morrow M, Khan SA, Cryns VL.

Breast Cancer Res Treat. 2008 Oct;111(3):411-7. Epub 2007 Oct 30.


αB-Crystallin is a Novel Oncoprotein Associated with Poor Prognosis in Breast Cancer.

Kim HS, Lee Y, Lim YA, Kang HJ, Kim LS.

J Breast Cancer. 2011 Mar;14(1):14-9. doi: 10.4048/jbc.2011.14.1.14. Epub 2011 Mar 31.


alphaB-crystallin suppresses oxidative stress-induced astrocyte apoptosis by inhibiting caspase-3 activation.

Shin JH, Kim SW, Lim CM, Jeong JY, Piao CS, Lee JK.

Neurosci Res. 2009 Aug;64(4):355-61. doi: 10.1016/j.neures.2009.04.006. Epub 2009 Apr 18.


ΑB-crystallin in clear cell renal cell carcinoma: tumor progression and prognostic significance.

Ho PY, Chueh SC, Chiou SH, Wang SM, Lin WC, Lee IL, Yang HY, Peng HC, Lai MK.

Urol Oncol. 2013 Oct;31(7):1367-77. doi: 10.1016/j.urolonc.2012.01.015. Epub 2012 Mar 13.


alphaB-crystallin as a marker of lymph node involvement in breast carcinoma.

Chelouche-Lev D, Kluger HM, Berger AJ, Rimm DL, Price JE.

Cancer. 2004 Jun 15;100(12):2543-8.


Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10703-8. doi: 10.1073/pnas.0712034105. Epub 2008 Jul 31.


Alpha B-crystallin is a new prognostic marker for laryngeal squamous cell carcinoma.

Mao Y, Zhang DW, Lin H, Xiong L, Liu Y, Li QD, Ma J, Cao Q, Chen RJ, Zhu J, Feng ZQ.

J Exp Clin Cancer Res. 2012 Dec 12;31:101. doi: 10.1186/1756-9966-31-101.


LEDGF binding to stress response element increases alphaB-crystallin expression in astrocytes with oxidative stress.

Shin JH, Piao CS, Lim CM, Lee JK.

Neurosci Lett. 2008 Apr 18;435(2):131-6. doi: 10.1016/j.neulet.2008.02.029. Epub 2008 Feb 20.


αB-crystallin regulates oxidative stress-induced apoptosis in cardiac H9c2 cells via the PI3K/AKT pathway.

Xu F, Yu H, Liu J, Cheng L.

Mol Biol Rep. 2013 Mar;40(3):2517-26. doi: 10.1007/s11033-012-2332-2. Epub 2012 Dec 1.


alphaB-crystallin: a novel p53-target gene required for p53-dependent apoptosis.

Watanabe G, Kato S, Nakata H, Ishida T, Ohuchi N, Ishioka C.

Cancer Sci. 2009 Dec;100(12):2368-75. doi: 10.1111/j.1349-7006.2009.01316.x. Epub 2009 Aug 18.

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