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Items: 1 to 20 of 99


Quality control: another player joins the ERAD cast.

Lord JM, Roberts LM, Stirling CJ.

Curr Biol. 2005 Dec 6;15(23):R963-4. Review.


Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.

Smith N, Adle DJ, Zhao M, Qin X, Kim H, Lee J.

J Biol Chem. 2016 Jul 15;291(29):15082-92. doi: 10.1074/jbc.M116.726265. Epub 2016 May 12.


A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradation.

Medicherla B, Kostova Z, Schaefer A, Wolf DH.

EMBO Rep. 2004 Jul;5(7):692-7. Epub 2004 May 28.


A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.


Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Huyer G, Piluek WF, Fansler Z, Kreft SG, Hochstrasser M, Brodsky JL, Michaelis S.

J Biol Chem. 2004 Sep 10;279(37):38369-78. Epub 2004 Jul 12.


Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

Jarosch E, Taxis C, Volkwein C, Bordallo J, Finley D, Wolf DH, Sommer T.

Nat Cell Biol. 2002 Feb;4(2):134-9.


Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Neuber O, Jarosch E, Volkwein C, Walter J, Sommer T.

Nat Cell Biol. 2005 Oct;7(10):993-8. Epub 2005 Sep 18.


A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis.

Tran JR, Tomsic LR, Brodsky JL.

J Biol Chem. 2011 Feb 18;286(7):5744-55. doi: 10.1074/jbc.M110.179259. Epub 2010 Dec 9.


The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

Ye Y, Meyer HH, Rapoport TA.

Nature. 2001 Dec 6;414(6864):652-6.


Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.


Key steps in ERAD of luminal ER proteins reconstituted with purified components.

Stein A, Ruggiano A, Carvalho P, Rapoport TA.

Cell. 2014 Sep 11;158(6):1375-1388. doi: 10.1016/j.cell.2014.07.050.


Cdc48p is UBX-linked to ER ubiquitin ligases.

Römisch K.

Trends Biochem Sci. 2006 Jan;31(1):24-5. Epub 2005 Nov 28. Review.


The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment.

Gauss R, Sommer T, Jarosch E.

EMBO J. 2006 May 3;25(9):1827-35. Epub 2006 Apr 13.


Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.

Alberts SM, Sonntag C, Schäfer A, Wolf DH.

J Biol Chem. 2009 Jun 12;284(24):16082-9. doi: 10.1074/jbc.M809282200. Epub 2009 Apr 9.


Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.


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