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Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes.

Timmons JA, Norrbom J, Schéele C, Thonberg H, Wahlestedt C, Tesch P.

Genomics. 2006 Jan;87(1):165-72. Epub 2005 Dec 2.


Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation.

Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME.

J Biol Chem. 2007 May 25;282(21):15439-50. Epub 2007 Apr 6.


Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.

Ling C, Poulsen P, Carlsson E, Ridderstråle M, Almgren P, Wojtaszewski J, Beck-Nielsen H, Groop L, Vaag A.

J Clin Invest. 2004 Nov;114(10):1518-26.


Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome.

Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H, Højlund K.

Diabetes. 2007 Sep;56(9):2349-55. Epub 2007 Jun 11.


A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR.

Diabetes. 2005 Jul;54(7):1926-33.


Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.

Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM.

Genes Dev. 2004 Feb 1;18(3):278-89. Epub 2004 Jan 26.


Fine needle aspiration coupled with real-time PCR: a painless methodology to study adaptive functional changes in skeletal muscle.

Guescini M, Fatone C, Stocchi L, Guidi C, Potenza L, Ditroilo M, Ranchelli A, Di Loreto C, Sisti D, De Feo P, Stocchi V.

Nutr Metab Cardiovasc Dis. 2007 Jun;17(5):383-93. Epub 2007 May 7.


Insulin-regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle.

Huang X, Eriksson KF, Vaag A, Lehtovirta M, Hansson M, Laurila E, Kanninen T, Olesen BT, Kurucz I, Koranyi L, Groop L.

Diabetes. 1999 Aug;48(8):1508-14.


Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle.

Ling C, Wegner L, Andersen G, Almgren P, Hansen T, Pedersen O, Groop L, Vaag A, Poulsen P.

Diabetologia. 2007 Aug;50(8):1615-20. Epub 2007 Jun 20.


Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects.

Karakelides H, Asmann YW, Bigelow ML, Short KR, Dhatariya K, Coenen-Schimke J, Kahl J, Mukhopadhyay D, Nair KS.

Diabetes. 2007 Nov;56(11):2683-9. Epub 2007 Jul 27.


Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1alpha or PGC-1beta and mitofusin 2 in skeletal muscle in type 2 diabetes.

Zorzano A, Hernández-Alvarez MI, Palacín M, Mingrone G.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1028-33. doi: 10.1016/j.bbabio.2010.02.017. Epub 2010 Feb 20. Review.


Coordination of metabolic plasticity in skeletal muscle.

Hood DA, Irrcher I, Ljubicic V, Joseph AM.

J Exp Biol. 2006 Jun;209(Pt 12):2265-75. Review.


PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice.

Rodríguez-Calvo R, Jové M, Coll T, Camins A, Sánchez RM, Alegret M, Merlos M, Pallàs M, Laguna JC, Vázquez-Carrera M.

J Gerontol A Biol Sci Med Sci. 2006 Aug;61(8):773-80.


Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training.

Zoll J, Steiner R, Meyer K, Vogt M, Hoppeler H, Flück M.

Eur J Appl Physiol. 2006 Mar;96(4):413-22. Epub 2005 Nov 26.


Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Rönn T, Poulsen P, Hansson O, Holmkvist J, Almgren P, Nilsson P, Tuomi T, Isomaa B, Groop L, Vaag A, Ling C.

Diabetologia. 2008 Jul;51(7):1159-68. doi: 10.1007/s00125-008-1018-8. Epub 2008 May 17.


Skeletal muscle mitochondrial protein metabolism and function in ageing and type 2 diabetes.

Barazzoni R.

Curr Opin Clin Nutr Metab Care. 2004 Jan;7(1):97-102. Review.


PGC-1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise.

Eivers SS, McGivney BA, Gu J, MacHugh DE, Katz LM, Hill EW.

Anim Genet. 2012 Apr;43(2):153-62. doi: 10.1111/j.1365-2052.2011.02238.x. Epub 2011 Sep 21.


Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process.

Barrientos A, Casademont J, Cardellach F, Ardite E, Estivill X, Urbano-Márquez A, Fernández-Checa JC, Nunes V.

Biochem Mol Med. 1997 Dec;62(2):165-71.


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