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Items: 1 to 20 of 213

1.

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC.

Science. 2005 Dec 9;310(5754):1642-6. Epub 2005 Nov 24.

2.

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

Foretz M, Hébrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, Sakamoto K, Andreelli F, Viollet B.

J Clin Invest. 2010 Jul;120(7):2355-69. doi: 10.1172/JCI40671. Epub 2010 Jun 23.

3.

Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats.

Jiang SJ, Dong H, Li JB, Xu LJ, Zou X, Wang KF, Lu FE, Yi P.

World J Gastroenterol. 2015 Jul 7;21(25):7777-85. doi: 10.3748/wjg.v21.i25.7777.

4.

Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.

Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J.

J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23.

5.

Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

Xie Z, Dong Y, Scholz R, Neumann D, Zou MH.

Circulation. 2008 Feb 19;117(7):952-62. doi: 10.1161/CIRCULATIONAHA.107.744490. Epub 2008 Feb 4.

6.

LKB1: a sweet side to Peutz-Jeghers syndrome?

Carling D.

Trends Mol Med. 2006 Apr;12(4):144-7. Epub 2006 Mar 10. Review.

PMID:
16530014
7.

Convergence of IPMK and LKB1-AMPK signaling pathways on metformin action.

Bang S, Chen Y, Ahima RS, Kim SF.

Mol Endocrinol. 2014 Jul;28(7):1186-93. doi: 10.1210/me.2014-1134. Epub 2014 May 30.

8.

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.

Kukidome D, Nishikawa T, Sonoda K, Imoto K, Fujisawa K, Yano M, Motoshima H, Taguchi T, Matsumura T, Araki E.

Diabetes. 2006 Jan;55(1):120-7.

9.

[From cancer to diabetes treatment : the tumor suppressor LKB1 as a new pharmacological target].

Foretz M, Guigas B, Viollet B.

Med Sci (Paris). 2006 Apr;22(4):348-50. French. No abstract available.

10.

Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle.

Branvold DJ, Allred DR, Beckstead DJ, Kim HJ, Fillmore N, Condon BM, Brown JD, Sudweeks SN, Thomson DM, Winder WW.

J Appl Physiol (1985). 2008 Oct;105(4):1218-27. doi: 10.1152/japplphysiol.00997.2007. Epub 2008 Jul 31.

11.

Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.

12.

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M.

Nature. 2005 Oct 20;437(7062):1109-11. Epub 2005 Sep 7.

PMID:
16148943
13.

LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.

Sriwijitkamol A, Ivy JL, Christ-Roberts C, DeFronzo RA, Mandarino LJ, Musi N.

Am J Physiol Endocrinol Metab. 2006 May;290(5):E925-32. Epub 2005 Dec 13.

14.

Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

Caton PW, Nayuni NK, Kieswich J, Khan NQ, Yaqoob MM, Corder R.

J Endocrinol. 2010 Apr;205(1):97-106. doi: 10.1677/JOE-09-0345. Epub 2010 Jan 21.

15.

Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP.

Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS.

Diabetes. 2008 Feb;57(2):306-14. Epub 2007 Oct 1.

16.

Medicine. Cancer-suppressing enzyme adds a link to type 2 diabetes.

Marx J.

Science. 2005 Nov 25;310(5752):1259. No abstract available.

PMID:
16311305
17.

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.

Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.

Mol Cell Biol. 2006 Nov;26(22):8217-27. Epub 2006 Sep 11.

18.

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

Jäger S, Handschin C, St-Pierre J, Spiegelman BM.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12017-22. Epub 2007 Jul 3.

19.

Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts.

Takemori H, Katoh Hashimoto Y, Nakae J, Olson EN, Okamoto M.

Endocr J. 2009;56(1):121-30. Epub 2008 Oct 22.

20.

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes.

Muraoka M, Fukushima A, Viengchareun S, Lombès M, Kishi F, Miyauchi A, Kanematsu M, Doi J, Kajimura J, Nakai R, Uebi T, Okamoto M, Takemori H.

Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1430-9. doi: 10.1152/ajpendo.00024.2009. Epub 2009 Apr 7.

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