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Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.

Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL.

J Endotoxin Res. 2005;11(6):363-8.


Innate recognition of lipopolysaccharide by Toll-like receptor 4/MD-2 and RP105/MD-1.

Miyake K, Ogata H, Nagai Y, Akashi S, Kimoto M.

J Endotoxin Res. 2000;6(5):389-91.


Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide.

Nagai Y, Shimazu R, Ogata H, Akashi S, Sudo K, Yamasaki H, Hayashi S, Iwakura Y, Kimoto M, Miyake K.

Blood. 2002 Mar 1;99(5):1699-705.


The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes.

Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K.

J Immunol. 2005 Jun 1;174(11):7043-9.


CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes.

Yazawa N, Fujimoto M, Sato S, Miyake K, Asano N, Nagai Y, Takeuchi O, Takeda K, Okochi H, Akira S, Tedder TF, Tamaki K.

Blood. 2003 Aug 15;102(4):1374-80. Epub 2003 Apr 24.


The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells.

Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbräuker I, Rajewsky K, Kimoto M, Tarakhovsky A.

J Exp Med. 2000 Jul 3;192(1):23-9.


Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.

Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL.

Nat Immunol. 2005 Jun;6(6):571-8. Epub 2005 Apr 24.


RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.

Liu B, Zhang N, Liu Z, Fu Y, Feng S, Wang S, Cao Y, Li D, Liang D, Li F, Song X, Yang Z.

Mol Cell Biochem. 2013 Jun;378(1-2):183-93. doi: 10.1007/s11010-013-1609-7. Epub 2013 Mar 13.


Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide.

Kimoto M, Nagasawa K, Miyake K.

Scand J Infect Dis. 2003;35(9):568-72. Review.


Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.

Ohto U, Miyake K, Shimizu T.

J Mol Biol. 2011 Nov 4;413(4):815-25. doi: 10.1016/j.jmb.2011.09.020. Epub 2011 Sep 19.


The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.

Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.

Int Immunol. 2012 Jun;24(6):389-400. doi: 10.1093/intimm/dxs040. Epub 2012 Feb 21.


RP105 is associated with MD-1 and transmits an activation signal in human B cells.

Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M.

Blood. 1998 Oct 15;92(8):2815-22.


The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.

Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, Ichihara Y, Wada T, Hirata Y, Suganami T, Izaki H, Akira S, Miyake K, Kanayama HO, Shimabukuro M, Sata M, Sasaoka T, Ogawa Y, Tobe K, Takatsu K, Nagai Y.

Diabetes. 2012 May;61(5):1199-209. doi: 10.2337/db11-1182. Epub 2012 Mar 6.


Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression.

Miyake K, Shimazu R, Kondo J, Niki T, Akashi S, Ogata H, Yamashita Y, Miura Y, Kimoto M.

J Immunol. 1998 Aug 1;161(3):1348-53.


Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS.

Dueñas AI, Orduña A, Crespo MS, García-Rodríguez C.

Int Immunol. 2004 Oct;16(10):1467-75. Epub 2004 Aug 31.


TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation.

Karper JC, Ewing MM, de Vries MR, de Jager SC, Peters EA, de Boer HC, van Zonneveld AJ, Kuiper J, Huizinga EG, Brondijk TH, Jukema JW, Quax PH.

PLoS One. 2013 Jul 2;8(7):e67923. doi: 10.1371/journal.pone.0067923. Print 2013.


The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface.

Fujimoto T, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T.

J Biol Chem. 2004 Nov 12;279(46):47431-7. Epub 2004 Aug 26.


TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.

Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, Kopf M, Marsland BJ.

J Immunol. 2007 Feb 15;178(4):2182-91.


TLR accessory molecules.

Akashi-Takamura S, Miyake K.

Curr Opin Immunol. 2008 Aug;20(4):420-5. doi: 10.1016/j.coi.2008.07.001. Epub 2008 Jul 24. Review.


Essential role of MD-2 in B-cell responses to lipopolysaccharide and Toll-like receptor 4 distribution.

Miyake K, Nagai Y, Akashi S, Nagafuku M, Ogata M, Kosugi A.

J Endotoxin Res. 2002;8(6):449-52.


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