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Items: 1 to 20 of 196

1.

Potent anti-muscarinic activity in a novel series of quinuclidine derivatives.

Starck JP, Talaga P, Quéré L, Collart P, Christophe B, Lo Brutto P, Jadot S, Chimmanamada D, Zanda M, Wagner A, Mioskowski C, Massingham R, Guyaux M.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):373-7. Epub 2005 Nov 3.

PMID:
16275087
2.

3-Heteroarylquinuclidin-2-ene derivatives as muscarinic antagonists: synthesis, structure-activity relationships and molecular modelling.

Nordvall G, Nilsson BM, Sundquist S, Johansson G, Glas G, Nilvebrant L, Hacksell U.

Prog Brain Res. 1996;109:141-5. No abstract available.

PMID:
9009700
3.

Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.

Starck JP, Provins L, Christophe B, Gillard M, Jadot S, Lo Brutto P, Quéré L, Talaga P, Guyaux M.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2675-8. doi: 10.1016/j.bmcl.2008.03.024. Epub 2008 Mar 18.

PMID:
18359633
4.

3-(2-Benzofuranyl)quinuclidin-2-ene derivatives: novel muscarinic antagonists.

Nordvall G, Sundquist S, Johansson G, Glas G, Nilvebrant L, Hacksell U.

J Med Chem. 1996 Aug 16;39(17):3269-77.

PMID:
8765510
5.

Quinuclidin-2-ene-based muscarinic antagonists.

Hacksell U, Nilsson BM, Nordvall G, Johansson G, Sundquist S, Nilvebrant L.

Life Sci. 1995;56(11-12):831-6.

PMID:
10188782
6.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.

Prat M, Buil MA, Fernández MD, Castro J, Monleón JM, Tort L, Casals G, Ferrer M, Huerta JM, Espinosa S, López M, Segarra V, Gavaldà A, Miralpeix M, Ramos I, Vilella D, González M, Córdoba M, Cárdenas A, Antón F, Beleta J, Ryder H.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3457-61. doi: 10.1016/j.bmcl.2011.03.096. Epub 2011 Apr 3.

PMID:
21524581
7.

Antimuscarinic 3-(2-furanyl)quinuclidin-2-ene derivatives: synthesis and structure-activity relationships.

Johansson G, Sundquist S, Nordvall G, Nilsson BM, Brisander M, Nilvebrant L, Hacksell U.

J Med Chem. 1997 Nov 7;40(23):3804-19.

PMID:
9371246
8.

Novel quinuclidine-based ligands for the muscarinic cholinergic receptor.

Saunders J, Cassidy M, Freedman SB, Harley EA, Iversen LL, Kneen C, MacLeod AM, Merchant KJ, Snow RJ, Baker R.

J Med Chem. 1990 Apr;33(4):1128-38.

PMID:
2319559
9.

Novel oxotremorine-related heterocyclic derivatives: Synthesis and in vitro pharmacology at the muscarinic receptor subtypes.

Dallanoce C, De Amici M, Barocelli E, Bertoni S, Roth BL, Ernsberger P, De Micheli C.

Bioorg Med Chem. 2007 Dec 15;15(24):7626-37. Epub 2007 Sep 11.

PMID:
17889543
10.

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification.

Boyle CD, Vice SF, Campion J, Chackalamannil S, Lankin CM, McCombie SW, Billard W, Binch H 3rd, Crosby G, Williams MC, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3479-82.

PMID:
12419388
11.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).

Prat M, Fernández D, Buil MA, Crespo MI, Casals G, Ferrer M, Tort L, Castro J, Monleón JM, Gavaldà A, Miralpeix M, Ramos I, Doménech T, Vilella D, Antón F, Huerta JM, Espinosa S, López M, Sentellas S, González M, Albertí J, Segarra V, Cárdenas A, Beleta J, Ryder H.

J Med Chem. 2009 Aug 27;52(16):5076-92. doi: 10.1021/jm900132z.

PMID:
19653626
12.

Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.

Del Bello F, Bonifazi A, Giorgioni G, Petrelli R, Quaglia W, Altomare A, Falcicchio A, Matucci R, Vistoli G, Piergentili A.

Eur J Med Chem. 2017 Sep 8;137:327-337. doi: 10.1016/j.ejmech.2017.06.004. Epub 2017 Jun 3.

PMID:
28609709
13.

Novel imidazole derivatives with subtype-selective antimuscarinic activity (2).

Miyachi H, Kiyota H, Segawa M.

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2163-8.

PMID:
9873506
14.

Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.

Dei S, Bellucci C, Buccioni M, Ferraroni M, Guandalini L, Manetti D, Marucci G, Matucci R, Nesi M, Romanelli MN, Scapecchi S, Teodori E.

Bioorg Med Chem. 2008 May 15;16(10):5490-500. doi: 10.1016/j.bmc.2008.04.013. Epub 2008 Apr 11.

PMID:
18455407
15.

Synthesis, affinity profile and functional activity of potent chiral muscarinic antagonists with a pyrrolidinylfuran structure.

Scapecchi S, Nesi M, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Manetti D, Martelli C, Martini E, Marucci G, Orlandi F, Romanelli MN, Teodori E, Cirilli R.

J Med Chem. 2010 Jan 14;53(1):201-7. doi: 10.1021/jm901048j.

PMID:
19928767
16.

The discovery of AZD9164, a novel muscarinic M3 antagonist.

Mete A, Bowers K, Chevalier E, Donald DK, Edwards H, Escott KJ, Ford R, Grime K, Millichip I, Teobald B, Russell V.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7440-6. doi: 10.1016/j.bmcl.2011.10.002. Epub 2011 Oct 8.

PMID:
22047691
17.

Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.

Naito R, Yonetoku Y, Okamoto Y, Toyoshima A, Ikeda K, Takeuchi M.

J Med Chem. 2005 Oct 20;48(21):6597-606.

PMID:
16220976
18.

3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships.

Nilsson BM, Sundquist S, Johansson G, Nordvall G, Glas G, Nilvebrant L, Hacksell U.

J Med Chem. 1995 Feb 3;38(3):473-87.

PMID:
7853341
19.

Stereoisomers of 3-(2,3-dihydrobenzofuran-2-yl)quinuclidine: preparation and muscarinic receptor affinities.

Johansson G, Brisander M, Sundquist S, Hacksell U.

Chirality. 1998;10(9):813-20.

PMID:
9839431
20.

Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.

Boyle CD, Chackalamannil S, Clader JW, Greenlee WJ, Josien HB, Kaminski JJ, Kozlowski JA, McCombie SW, Nazareno DV, Tagat JR, Wang Y, Zhou G, Billard W, Binch H, Crosby G, Cohen-Williams M, Coffin VL, Cox KA, Grotz DE, Duffy RA, Ruperto V, Lachowicz JE.

Bioorg Med Chem Lett. 2001 Sep 3;11(17):2311-4.

PMID:
11527721

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