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Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind JS.

Cancer Res. 2005 Nov 1;65(21):9953-61.


Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of rapamycin, and p70 S6 kinase signaling pathways.

Gerasimovskaya EV, Tucker DA, Weiser-Evans M, Wenzlau JM, Klemm DJ, Banks M, Stenmark KR.

J Biol Chem. 2005 Jan 21;280(3):1838-48. Epub 2004 Nov 1.


The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation.

Follo MY, Mongiorgi S, Bosi C, Cappellini A, Finelli C, Chiarini F, Papa V, Libra M, Martinelli G, Cocco L, Martelli AM.

Cancer Res. 2007 May 1;67(9):4287-94.


The molecular target of rapamycin (mTOR) as a therapeutic target against cancer.

Mita MM, Mita A, Rowinsky EK.

Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S169-77. Review.


Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma.

Peponi E, Drakos E, Reyes G, Leventaki V, Rassidakis GZ, Medeiros LJ.

Am J Pathol. 2006 Dec;169(6):2171-80.


A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer.

Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind JS.

Cancer Res. 2008 Feb 15;68(4):1144-53. doi: 10.1158/0008-5472.CAN-07-1756.


Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.

Woodard J, Sassano A, Hay N, Platanias LC.

Clin Cancer Res. 2008 Jul 15;14(14):4640-9. doi: 10.1158/1078-0432.CCR-07-5232.


Determinants of rapamycin sensitivity in breast cancer cells.

Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F.

Clin Cancer Res. 2004 Feb 1;10(3):1013-23.


The rapamycin-sensitive signal transduction pathway as a target for cancer therapy.

Hidalgo M, Rowinsky EK.

Oncogene. 2000 Dec 27;19(56):6680-6. Review.


Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.

Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, Majchrzak B, Sonenberg N, Hay N, Fish EN, Platanias LC.

J Biol Chem. 2003 Jul 25;278(30):27772-80. Epub 2003 May 20.


Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancer.

Nozawa H, Watanabe T, Nagawa H.

Cancer Lett. 2007 Jun 18;251(1):105-13. Epub 2006 Dec 18.


Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of rapamycin pathway.

Nathan CO, Amirghahari N, Abreo F, Rong X, Caldito G, Jones ML, Zhou H, Smith M, Kimberly D, Glass J.

Clin Cancer Res. 2004 Sep 1;10(17):5820-7.


Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.

Clin Cancer Res. 2004 Dec 1;10(23):8059-67.


Involvement of the Akt/mTOR pathway on EGF-induced cell transformation.

Nomura M, He Z, Koyama I, Ma WY, Miyamoto K, Dong Z.

Mol Carcinog. 2003 Sep;38(1):25-32.


Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells.

Lal L, Li Y, Smith J, Sassano A, Uddin S, Parmar S, Tallman MS, Minucci S, Hay N, Platanias LC.

Blood. 2005 Feb 15;105(4):1669-77. Epub 2004 Oct 7.


Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma.

Clark CA, McEachern MD, Shah SH, Rong Y, Rong X, Smelley CL, Caldito GC, Abreo FW, Nathan CO.

Cancer Prev Res (Phila). 2010 Dec;3(12):1586-95. doi: 10.1158/1940-6207.CAPR-09-0244. Epub 2010 Sep 17.

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