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Proteolysis of CCN1 by plasmin: functional implications.

Pendurthi UR, Tran TT, Post M, Rao LV.

Cancer Res. 2005 Nov 1;65(21):9705-11.


The matrix protein CCN1 (CYR61) promotes proliferation, migration and tube formation of endothelial progenitor cells.

Yu Y, Gao Y, Wang H, Huang L, Qin J, Guo R, Song M, Yu S, Chen J, Cui B, Gao P.

Exp Cell Res. 2008 Oct 15;314(17):3198-208. doi: 10.1016/j.yexcr.2008.08.001. Epub 2008 Aug 13.


The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration.

Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B.

Blood. 2007 Aug 1;110(3):877-85. Epub 2007 Apr 11.


Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells.

Chen N, Leu SJ, Todorovic V, Lam SC, Lau LF.

J Biol Chem. 2004 Oct 15;279(42):44166-76. Epub 2004 Aug 10.


CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells.

Si W, Kang Q, Luu HH, Park JK, Luo Q, Song WX, Jiang W, Luo X, Li X, Yin H, Montag AG, Haydon RC, He TC.

Mol Cell Biol. 2006 Apr;26(8):2955-64.


Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing.

Athanasopoulos AN, Schneider D, Keiper T, Alt V, Pendurthi UR, Liegibel UM, Sommer U, Nawroth PP, Kasperk C, Chavakis T.

J Biol Chem. 2007 Sep 14;282(37):26746-53. Epub 2007 Jul 10.


Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina.

Choi J, Lin A, Shrier E, Lau LF, Grant MB, Chaqour B.

J Biol Chem. 2013 Aug 9;288(32):23075-89. doi: 10.1074/jbc.M113.475418. Epub 2013 Jun 24.


Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells.

Gery S, Xie D, Yin D, Gabra H, Miller C, Wang H, Scott D, Yi WS, Popoviciu ML, Said JW, Koeffler HP.

Clin Cancer Res. 2005 Oct 15;11(20):7243-54.


A novel mechanism of plasmin-induced mitogenesis in fibroblasts.

Mandal SK, Rao LV, Tran TT, Pendurthi UR.

J Thromb Haemost. 2005 Jan;3(1):163-9.


Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors.

Guillon-Munos A, Oikonomopoulou K, Michel N, Smith CR, Petit-Courty A, Canepa S, Reverdiau P, Heuzé-Vourc'h N, Diamandis EP, Courty Y.

J Biol Chem. 2011 Jul 22;286(29):25505-18. doi: 10.1074/jbc.M110.213231. Epub 2011 May 31.


Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney.

Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1363-72. Epub 2007 Aug 15.


Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61).

Leu SJ, Liu Y, Chen N, Chen CC, Lam SC, Lau LF.

J Biol Chem. 2003 Sep 5;278(36):33801-8. Epub 2003 Jun 24.


CCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model.

Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M, Kita T, Tanaka M.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1077-83. doi: 10.1161/ATVBAHA.108.162362. Epub 2008 Apr 3.


Functional domains of CCN1 (Cyr61) regulate breast cancer progression.

O'Kelly J, Chung A, Lemp N, Chumakova K, Yin D, Wang HJ, Said J, Gui D, Miller CW, Karlan BY, Koeffler HP.

Int J Oncol. 2008 Jul;33(1):59-67.


Pancreatic tumor cell secreted CCN1/Cyr61 promotes endothelial cell migration and aberrant neovascularization.

Maity G, Mehta S, Haque I, Dhar K, Sarkar S, Banerjee SK, Banerjee S.

Sci Rep. 2014 May 16;4:4995. doi: 10.1038/srep04995.


Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway.

Pendurthi UR, Ngyuen M, Andrade-Gordon P, Petersen LC, Rao LV.

Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1421-6.


Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis.

Koon HW, Zhao D, Xu H, Bowe C, Moss A, Moyer MP, Pothoulakis C.

Am J Pathol. 2008 Aug;173(2):400-10. doi: 10.2353/ajpath.2008.080222. Epub 2008 Jul 3.


Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion.

Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML.

J Biol Chem. 2008 Jun 6;283(23):15807-15. doi: 10.1074/jbc.M708933200. Epub 2008 Apr 1. Retraction in: J Biol Chem. 2016 Dec 30;291(53):27433.

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