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Items: 1 to 20 of 95

1.

Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.

Lin CC, Xu C, Teng A, Yeh LT, Peterson J.

J Clin Pharmacol. 2005 Nov;45(11):1250-8.

PMID:
16239358
2.

Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.

Lin CC, Fang C, Benetton S, Xu GF, Yeh LT.

Antimicrob Agents Chemother. 2006 Sep;50(9):2926-31.

3.

Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir.

Cundy KC.

Clin Pharmacokinet. 1999 Feb;36(2):127-43. Review.

PMID:
10092959
4.

Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers.

Lin CC, Philips L, Xu C, Yeh LT.

J Clin Pharmacol. 2004 Mar;44(3):265-75.

PMID:
14973309
5.

Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.

Tillmann HL.

Curr Opin Investig Drugs. 2007 Aug;8(8):682-90.

PMID:
17668370
6.

Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.

Biessen EA, Valentijn AR, De Vrueh RL, Van De Bilt E, Sliedregt LA, Prince P, Bijsterbosch MK, Van Boom JH, Van Der Marel GA, Abrahams PJ, Van Berkel TJ.

FASEB J. 2000 Sep;14(12):1784-92.

8.

Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.

Lin CC, Yeh LT, Vitarella D, Hong Z, Erion MD.

Antivir Chem Chemother. 2004 Nov;15(6):307-17.

PMID:
15646644
9.

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

Starrett JE Jr, Tortolani DR, Russell J, Hitchcock MJ, Whiterock V, Martin JC, Mansuri MM.

J Med Chem. 1994 Jun 10;37(12):1857-64.

PMID:
8021925
10.

Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.

Shaw JP, Louie MS, Krishnamurthy VV, Arimilli MN, Jones RJ, Bidgood AM, Lee WA, Cundy KC.

Drug Metab Dispos. 1997 Mar;25(3):362-6.

11.

Pharmacokinetics in mice of the anti-retrovirus agent 9-(2-phosphonylmethoxyethyl)adenine.

Naesens L, Balzarini J, De Clercq E.

Drug Metab Dispos. 1992 Sep-Oct;20(5):747-52.

PMID:
1358582
12.

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.

Annaert P, Gosselin G, Pompon A, Benzaria S, Valette G, Imbach JL, Naesens L, Hatse S, de Clercq E, Van den Mooter G, Kinget R, Augustijns P.

Pharm Res. 1998 Feb;15(2):239-45.

PMID:
9523310
14.

Pharmacokinetics and food interaction of a novel prodrug of tenofovir, tenofovir dipivoxil fumarate, in healthy volunteers.

Lu C, Jia Y, Chen L, Ding Y, Yang J, Chen M, Song Y, Sun X, Wen A.

J Clin Pharm Ther. 2013 Apr;38(2):136-40. doi: 10.1111/jcpt.12023.

PMID:
23278367
15.

Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD.

J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216.

PMID:
18173234
16.

Pharmacokinetics, safety and tolerance of single- and multiple-dose adefovir dipivoxil in healthy Chinese subjects.

Sun DQ, Wang HS, Ni MY, Wang BJ, Guo RC.

Br J Clin Pharmacol. 2007 Jan;63(1):15-23.

17.

Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.

Bi HC, Zhong GP, Zhou S, Chen X, Huang M.

Rapid Commun Mass Spectrom. 2005;19(20):2911-7.

PMID:
16167376
19.

Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.

de Vrueh RL, Rump ET, van De Bilt E, van Veghel R, Balzarini J, Biessen EA, van Berkel TJ, Bijsterbosch MK.

Antimicrob Agents Chemother. 2000 Mar;44(3):477-83.

20.

Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.

Rossi L, Dominici S, Serafini S, Casabianca A, Cerasi A, Chiarantini L, Celeste AG, Cappellacci L, Franchetti P, Grifantini M, Magnani M.

J Antimicrob Chemother. 2002 Sep;50(3):365-74.

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