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Items: 1 to 20 of 79

1.

Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation.

Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH.

FASEB J. 2005 Dec;19(14):2083-4. Epub 2005 Oct 17.

PMID:
16230335
2.

The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.

Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH.

J Neurosci. 2005 Jan 26;25(4):823-9.

3.

Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.

Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R.

Int J Dev Neurosci. 2009 Oct;27(6):517-23. doi: 10.1016/j.ijdevneu.2009.06.011. Epub 2009 Jul 7.

PMID:
19589380
4.

Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats.

Ashok A, Rai NK, Tripathi S, Bandyopadhyay S.

Toxicol Sci. 2015 Jan;143(1):64-80. doi: 10.1093/toxsci/kfu208. Epub 2014 Oct 6.

PMID:
25288670
5.

Thiamine deficiency increases β-secretase activity and accumulation of β-amyloid peptides.

Zhang Q, Yang G, Li W, Fan Z, Sun A, Luo J, Ke ZJ.

Neurobiol Aging. 2011 Jan;32(1):42-53. doi: 10.1016/j.neurobiolaging.2009.01.005. Epub 2009 Feb 23.

PMID:
19233513
6.

Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology.

Zhao Z, Ho L, Wang J, Qin W, Festa ED, Mobbs C, Hof P, Rocher A, Masur S, Haroutunian V, Pasinetti GM.

FASEB J. 2005 Dec;19(14):2081-2. Epub 2005 Sep 26.

PMID:
16186174
7.

Environmental risk factors and the developmental basis for Alzheimer's disease.

Zawia NH, Basha MR.

Rev Neurosci. 2005;16(4):325-37. Review.

PMID:
16519009
8.

Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases.

Böhme L, Hoffmann T, Manhart S, Wolf R, Demuth HU.

Biol Chem. 2008 Aug;389(8):1055-66. doi: 10.1515/BC.2008.125.

PMID:
18979630
9.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248
10.

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation.

White AR, Maher F, Brazier MW, Jobling MF, Thyer J, Stewart LR, Thompson A, Gibson R, Masters CL, Multhaup G, Beyreuther K, Barrow CJ, Collins SJ, Cappai R.

Brain Res. 2003 Mar 21;966(2):231-44.

PMID:
12618346
11.

Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.

Castorina A, Tiralongo A, Giunta S, Carnazza ML, Scapagnini G, D'Agata V.

Cell Biol Toxicol. 2010 Aug;26(4):367-77. doi: 10.1007/s10565-009-9149-3. Epub 2010 Jan 29.

PMID:
20111991
12.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

13.

Beta-amyloid, neuronal death and Alzheimer's disease.

Carter J, Lippa CF.

Curr Mol Med. 2001 Dec;1(6):733-7. Review.

PMID:
11899259
14.

Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.

Li Y, Zhou W, Tong Y, He G, Song W.

FASEB J. 2006 Feb;20(2):285-92.

PMID:
16449801
15.

Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease.

Srivareerat M, Tran TT, Salim S, Aleisa AM, Alkadhi KA.

Neurobiol Aging. 2011 May;32(5):834-44. doi: 10.1016/j.neurobiolaging.2009.04.015. Epub 2009 May 22.

PMID:
19464074
16.

p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.

Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, Sun Y, Yang M, Lim Y, Evin G, Zhong JH, Masters C, Zhou XF.

J Neurosci. 2011 Feb 9;31(6):2292-304. doi: 10.1523/JNEUROSCI.2733-10.2011.

17.

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation.

Zheng W, Xin N, Chi ZH, Zhao BL, Zhang J, Li JY, Wang ZY.

FASEB J. 2009 Dec;23(12):4207-17. doi: 10.1096/fj.09-135749. Epub 2009 Aug 13.

PMID:
19679638
18.

Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.

Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.

J Neurosci Res. 2011 Jun;89(6):822-32. doi: 10.1002/jnr.22618. Epub 2011 Mar 23.

PMID:
21433051
19.

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.

Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.

FASEB J. 2005 May;19(7):739-49.

PMID:
15857888

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