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Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).

Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. Epub 2005 Oct 14.


Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor.

Wang YH, Shi CX, Dong F, Sheng JW, Xu YF.

Br J Pharmacol. 2008 May;154(2):429-39. doi: 10.1038/bjp.2008.95. Epub 2008 Apr 14.


Isolation and characterization of I(Kr) in cardiac myocytes by Cs+ permeation.

Zhang S.

Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1038-49. Epub 2005 Oct 14.


Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.

Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S.

J Biol Chem. 2011 Oct 7;286(40):34664-74. doi: 10.1074/jbc.M111.253351. Epub 2011 Aug 15.


Involvement of caveolin in low K+-induced endocytic degradation of cell-surface human ether-a-go-go-related gene (hERG) channels.

Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S.

J Biol Chem. 2010 Aug 27;285(35):27259-64. doi: 10.1074/jbc.M110.124909. Epub 2010 Jul 6.


Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.

Massaeli H, Guo J, Xu J, Zhang S.

Circ Res. 2010 Apr 2;106(6):1072-82. doi: 10.1161/CIRCRESAHA.109.215970. Epub 2010 Feb 4.


Identification of Ikr kinetics and drug binding in native myocytes.

Zhou Q, Zygmunt AC, Cordeiro JM, Siso-Nadal F, Miller RE, Buzzard GT, Fox JJ.

Ann Biomed Eng. 2009 Jul;37(7):1294-309. doi: 10.1007/s10439-009-9690-5. Epub 2009 Apr 8.


Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol.

Balijepalli RC, Delisle BP, Balijepalli SY, Foell JD, Slind JK, Kamp TJ, January CT.

Channels (Austin). 2007 Jul-Aug;1(4):263-72. Epub 2007 Aug 27.


Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.

McBride CM, Smith AM, Smith JL, Reloj AR, Velasco EJ, Powell J, Elayi CS, Bartos DC, Burgess DE, Delisle BP.

J Membr Biol. 2013 May;246(5):355-64. doi: 10.1007/s00232-013-9539-6. Epub 2013 Apr 2.


Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: interaction of trafficking and gating.

Balijepalli SY, Lim E, Concannon SP, Chew CL, Holzem KE, Tester DJ, Ackerman MJ, Delisle BP, Balijepalli RC, January CT.

Circulation. 2012 Dec 11;126(24):2809-18. doi: 10.1161/CIRCULATIONAHA.112.118018. Epub 2012 Nov 6.


Deciphering hERG channels: molecular basis of the rapid component of the delayed rectifier potassium current.

Jonsson MK, van der Heyden MA, van Veen TA.

J Mol Cell Cardiol. 2012 Sep;53(3):369-74. doi: 10.1016/j.yjmcc.2012.06.011. Epub 2012 Jun 26. Review.


Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, Zhang S.

J Pharmacol Exp Ther. 2007 Jun;321(3):911-20. Epub 2007 Mar 21.


Expression of distinct ERG proteins in rat, mouse, and human heart. Relation to functional I(Kr) channels.

Pond AL, Scheve BK, Benedict AT, Petrecca K, Van Wagoner DR, Shrier A, Nerbonne JM.

J Biol Chem. 2000 Feb 25;275(8):5997-6006.


Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.

Nalos L, de Boer TP, Houtman MJ, Rook MB, Vos MA, van der Heyden MA.

Eur J Pharmacol. 2011 Feb 10;652(1-3):96-103. doi: 10.1016/j.ejphar.2010.10.093. Epub 2010 Nov 27.


A minK-HERG complex regulates the cardiac potassium current I(Kr).

McDonald TV, Yu Z, Ming Z, Palma E, Meyers MB, Wang KW, Goldstein SA, Fishman GI.

Nature. 1997 Jul 17;388(6639):289-92.


Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Grunnet M, Abbruzzese J, Sachse FB, Sanguinetti MC.

Mol Pharmacol. 2011 Jan;79(1):1-9. doi: 10.1124/mol.110.067728. Epub 2010 Sep 27.


Downregulation of the HERG (KCNH2) K(+) channel by ceramide: evidence for ubiquitin-mediated lysosomal degradation.

Chapman H, Ramström C, Korhonen L, Laine M, Wann KT, Lindholm D, Pasternack M, Törnquist K.

J Cell Sci. 2005 Nov 15;118(Pt 22):5325-34. Epub 2005 Nov 1.


Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes.

Toyoda F, Ding WG, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H.

J Membr Biol. 2010 Jun;235(2):73-87. doi: 10.1007/s00232-010-9257-2. Epub 2010 May 19.


Transfection by eukaryotic expression vector pcDNA3-HERG inhibits the cultured neonatal rabbit ventricular myocyte hypertrophy induced by phenylephrine.

Zhao Y, Xu Y, Cui C, Li Y, Zeng Y.

Cardiovasc Pathol. 2012 Jul-Aug;21(4):339-45. doi: 10.1016/j.carpath.2011.09.006. Epub 2011 Nov 18.


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