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Items: 1 to 20 of 218

1.

Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments.

Buchete NV, Tycko R, Hummer G.

J Mol Biol. 2005 Nov 4;353(4):804-21. Epub 2005 Sep 15.

PMID:
16213524
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Amyloid fibril formation by A beta 16-22, a seven-residue fragment of the Alzheimer's beta-amyloid peptide, and structural characterization by solid state NMR.

Balbach JJ, Ishii Y, Antzutkin ON, Leapman RD, Rizzo NW, Dyda F, Reed J, Tycko R.

Biochemistry. 2000 Nov 14;39(45):13748-59.

PMID:
11076514
4.

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.

Petkova AT, Ishii Y, Balbach JJ, Antzutkin ON, Leapman RD, Delaglio F, Tycko R.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16742-7. Epub 2002 Dec 12.

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8.

Role of water in protein aggregation and amyloid polymorphism.

Thirumalai D, Reddy G, Straub JE.

Acc Chem Res. 2012 Jan 17;45(1):83-92. doi: 10.1021/ar2000869. Epub 2011 Jul 15.

9.

Understanding amyloid fibril nucleation and aβ oligomer/drug interactions from computer simulations.

Nguyen P, Derreumaux P.

Acc Chem Res. 2014 Feb 18;47(2):603-11. doi: 10.1021/ar4002075. Epub 2013 Dec 24. Review.

PMID:
24368046
10.

The Alzheimer's amyloid-β(1-42) peptide forms off-pathway oligomers and fibrils that are distinguished structurally by intermolecular organization.

Tay WM, Huang D, Rosenberry TL, Paravastu AK.

J Mol Biol. 2013 Jul 24;425(14):2494-508. doi: 10.1016/j.jmb.2013.04.003. Epub 2013 Apr 11.

PMID:
23583777
11.

Aβ monomers transiently sample oligomer and fibril-like configurations: ensemble characterization using a combined MD/NMR approach.

Rosenman DJ, Connors CR, Chen W, Wang C, García AE.

J Mol Biol. 2013 Sep 23;425(18):3338-59. doi: 10.1016/j.jmb.2013.06.021. Epub 2013 Jun 25.

12.

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils.

Antzutkin ON, Balbach JJ, Leapman RD, Rizzo NW, Reed J, Tycko R.

Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13045-50.

13.

Structural insights into the polymorphism of amyloid-like fibrils formed by region 20-29 of amylin revealed by solid-state NMR and X-ray fiber diffraction.

Madine J, Jack E, Stockley PG, Radford SE, Serpell LC, Middleton DA.

J Am Chem Soc. 2008 Nov 12;130(45):14990-5001. doi: 10.1021/ja802483d. Epub 2008 Oct 21.

PMID:
18937465
14.

A new structural model of Aβ40 fibrils.

Bertini I, Gonnelli L, Luchinat C, Mao J, Nesi A.

J Am Chem Soc. 2011 Oct 12;133(40):16013-22. doi: 10.1021/ja2035859. Epub 2011 Sep 21.

PMID:
21882806
15.

Structure and dynamics of the Abeta(21-30) peptide from the interplay of NMR experiments and molecular simulations.

Fawzi NL, Phillips AH, Ruscio JZ, Doucleff M, Wemmer DE, Head-Gordon T.

J Am Chem Soc. 2008 May 14;130(19):6145-58. doi: 10.1021/ja710366c. Epub 2008 Apr 16. Erratum in: J Am Chem Soc. 2011 Aug 3;133(30):11816.

16.

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes.

Qiang W, Yau WM, Lu JX, Collinge J, Tycko R.

Nature. 2017 Jan 12;541(7636):217-221. doi: 10.1038/nature20814. Epub 2017 Jan 4.

PMID:
28052060
17.

Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization.

Potapov A, Yau WM, Ghirlando R, Thurber KR, Tycko R.

J Am Chem Soc. 2015 Jul 1;137(25):8294-307. doi: 10.1021/jacs.5b04843. Epub 2015 Jun 19.

PMID:
26068174
18.

Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril.

McDonald M, Box H, Bian W, Kendall A, Tycko R, Stubbs G.

J Mol Biol. 2012 Oct 26;423(3):454-61. doi: 10.1016/j.jmb.2012.08.004. Epub 2012 Aug 16.

19.

Induced beta-barrel formation of the Alzheimer's Abeta25-35 oligomers on carbon nanotube surfaces: implication for amyloid fibril inhibition.

Fu Z, Luo Y, Derreumaux P, Wei G.

Biophys J. 2009 Sep 16;97(6):1795-803. doi: 10.1016/j.bpj.2009.07.014.

20.

Antiparallel β-Sheet Structure within the C-Terminal Region of 42-Residue Alzheimer's Amyloid-β Peptides When They Form 150-kDa Oligomers.

Huang D, Zimmerman MI, Martin PK, Nix AJ, Rosenberry TL, Paravastu AK.

J Mol Biol. 2015 Jul 3;427(13):2319-28. doi: 10.1016/j.jmb.2015.04.004. Epub 2015 Apr 16.

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